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基于pH响应的聚乙烯氧化物电纳米纤维用于受控的药物释放在受感染的伤口治疗中

Qian-Yu Yuan¹, Lan Yang¹, Bing-Chiuan Shiu^2,3

¹School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China.

|January 28, 2026

概括

这项研究开发了一种新的聚乙烯氧化物 (PEO) 复合纤维膜,用于感染伤口. PEO膜提供受控的药物释放,pH敏感性和抗菌性质,以改善伤口愈合.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
伤口愈合技术伤口愈合技术

背景情况:

受感染的伤口呈现出复杂的微环境,挑战传统的药物输送.
有效的治疗需要能够控制药物释放和对抗感染的材料.
开发先进的伤口护理解决方案对于患者的康复至关重要.

研究的目的:

创建基于聚乙烯氧化物 (PEO) 的复合纤维膜,以增强在受感染的伤口中的药物输送.
通过定制材料组成来实现按需药物释放和整合多种功能.
为了研究基托 (CS) 和酸 (Asc) 对膜性质和性能的影响.

主要方法:

用PEO作为主要框架制备复合纤维膜,其中包括素 (CS) 和酸 (Asc).
膜的微观结构,纤维直径和药物释放动态的表征.
在体外评估pH的敏感性,抗氧化活性和抗菌疗效对大肠杆菌 (E. coli) 和黄金杆菌 (Staphylococcus aureus) 的抗菌效果.

主要成果:

在PEO矩阵中调整CS含量调整了初始药物释放率和持续释放持续时间.
复合膜表现出pH敏感的药物释放,在感染伤口的轻微酸性条件下加速释放.
膜表现出显著的抗氧化活性,并有效地抑制了大肠杆菌和金黄色杆菌的生长.

结论:

以PEO为基础的复合纤维提供可调节的药物释放配置文件和感染伤口管理的理想功能.
开发出来的膜显示出作为在伤口护理中用于药物输送和组织修复的多功能平台的潜力.
集成CS和Asc为创建先进的伤口愈合材料提供了一个有前途的战略.

关键词:

基多酸盐的使用方法复合纤维膜是一种复合纤维膜.药物输送是药物输送的过程.聚乙烯氧化物聚乙烯氧化物

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