从3D打印双叶片中调制药物释放:3D打印双叶片中的可调制药物释放:3D打印双叶片中的可调制药物释放:3D打印双叶片中的可调制药物释放:3D打印3D打印3D打印3D打印3D打印3D打印3D打印3D打印3D打印3D打印3D打印3D打印3D
Sangyeob Lee1, Eon Soo Song1, Eungyeop Lee1
1BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE, MRC), College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Polymers
|January 28, 2026
概括
这项研究介绍了一种3D打印方法,用于创建具有可调节药物释放的双层平板电脑. 通过调整结沉积建模 (FDM) 打印片中的层比,可以在不改变配方的情况下实现受控的西奥菲林释放.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 控制释放剂量形式对于优化治疗疗效和患者服药性至关重要.
- 3D打印为制造具有量身定制的释放配置文件的复杂药物输送系统提供了一个有前途的途径.
研究的目的:
- 开发和评估一种实用的3D打印方法,用于制造口服可控释放双层药片.
- 通过控制通过融合沉积建模 (FDM) 制造的双层片中的层比来证明药物释放的调节.
主要方法:
- 使用热挤出 (HME) 用Kolicoat® IR或基纤维素制备了带有神素的细丝.
- 导线的机械性能被评估为适用于FDM3D打印.
- 双层平板电脑是使用双喷嘴FDM3D打印机制造的,其层次比例不同.
- 进行了物理化学表征 (SEM,DSC,XRD,FTIR) 和体外药物释放研究.
主要成果:
- 制造的纤维丝表现出适合FDM打印的机械性能.
- 物理化学分析证实了药物在聚合物矩阵中的分散.
- 成功制造了具有不同层次比例的双层药片,根据成分表现出不同的药物释放概况.
- 通过改变双层结构,有效控制药物释放.
结论:
- 结合的HME-FDM 3D打印方法使双层结构的几何调制成为可控的药物释放.
- 这种方法为个性化的口服药物递送提供了一个实用的平台,而不会增加配方复杂性.
- 双层3D打印片中的层比控制是调节药物释放动态的有效策略.
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