作为药物不良反应的cytopenias:报告结构,速率和趋势的10年分析
Ivana Stević1, Slobodan M Janković2, Marija Mihailović3
1Department of Social Pharmacy and Pharmaceutical Legislation, Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia.
Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
概括
药物诱导的细胞衰竭 (DICs) 报告不足. 这项研究分析了全球和塞尔维亚的ADR报告,发现塞尔维亚报告增加,但全球贫血病例减少. 早期检测措施至关重要.
科学领域:
- 药物监督 药物监督 药物监督
- 血液学 血液学 血液学
- 药品安全 药品安全
背景情况:
- 由于症状延迟和复杂的诊断,药物诱导的细胞衰竭 (DICs) 经常被报告不足.
- 自发药物不良反应 (ADR) 报告系统对于药物监测至关重要.
研究的目的:
- 分析全球和塞尔维亚报告的药物诱导细胞衰竭 (白血病,贫血,血栓衰竭,总细胞衰竭) 的结构,速率和趋势.
- 用现实数据比较塞尔维亚与世界其他国家之间的报告模式.
主要方法:
- 对2014-2023年药物诱导细胞衰竭 (DICs) 的VigiBase数据的分析.
- 计算每10万人/年报告率的计算.
- 统计分析包括千平方测试和连接点分析.
主要成果:
- 塞尔维亚的白血病报告率 (1.26/百万/年) 比全球平均水平 (0.96/百万/年) 高.
- 全球贫血报告随着时间的推移而减少,而塞尔维亚报告的所有细胞衰竭都显示出持续增加.
- 最严重的DIC发生在45-64岁的女性中;医生报告了塞尔维亚76.34%的病例,全球为31.72%.
结论:
- 在DIC报告中存在上升趋势,但在塞尔维亚报告的波动性更高.
- 提高DIC的早期检测需要改善所有医疗保健专业人员 (包括药剂师) 获取血液样本结果的机会.
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