开发和评估Platanus orientalis L.提取物载脂质体用于增强伤口愈合
Firdevs Demirel1,2, Ali Asram Sağıroğlu3, Gülbahar Özge Alim Toraman2
1Institute of Health Sciences, İstanbul University, 34126 Istanbul, Turkey.
Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
概括
这项研究开发了Platanus orientalis提取物的脂质体配方,用于伤口愈合. 优化的脂质体表现出增强的体外伤口关闭和持续的氨酸释放,表明局部治疗的潜力.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 自然产品化学 自然产品化学
- 生物材料科学 生物材料科学
背景情况:
- 伤口愈合是一个复杂的过程,受炎症和氧化应激的影响.
- 植物衍生化合物为组织修复提供了潜在的治疗益处.
- 普拉塔努斯东方提取物含有具有抗氧化特性的生物活性化合物.
研究的目的:
- 开发和描述Platanus orientalis提取物用于伤口愈合的脂质体配方.
- 评估植物化学特征,并确定奎尔素作为关键活性化合物.
- 评估体外脂肪体输送系统的有效性,安全性和稳定性.
主要方法:
- 使用LC-HRMS.Platanus orientalis提取物的制备和表征.
- 通过薄膜水化和超声波来制备含奎尔素的脂质体.
- 评估脂质体属性 (大小,PDI,泽塔潜力,EE,TDC),体外释放,细胞毒性和伤口愈合分析.
主要成果:
- 优化的脂质体表现出有利的特征:106.6 nm大小,0.11 PDI,-14.1 mV泽塔电位,72.25% EE和96.15% TDC.
- 在体外持续释放氨酸 (~75%在24小时内) 和在5°C下60天的物理稳定性.
- 该配方没有表现出细胞毒性,并且在体外显著增强了伤口关闭.
结论:
- 普拉塔努斯东方提取物的脂质体输送提供了一个生物相容的持续释放系统.
- 开发的配方显示了提高伤口愈合效率的巨大潜力.
- 这种脂质体系统支持在先进的局部伤口护理疗法中的潜在应用.
相关概念视频
Self-Evaluation: Self-Enhancement and Self-Verification
5.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K
Impact Loading
691
Impact loading occurs when a moving object collides with a stationary structure, such as a rod with a uniform cross-sectional area fixed at one end. Under these conditions, the rod absorbs the kinetic energy from the striking object, leading to deformation and subsequent stress development. As the rod returns to its original position and reaches maximum stress, the absorbed energy, initially manifested as kinetic energy, transforms entirely into strain energy.
In cases of elastic deformation,...
In cases of elastic deformation,...
691
Bioavailability Enhancement: Drug Solubility Enhancement
255
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
255
Distributed Loads
967
Distributed loads are a common type of load that engineers and scientists encounter in various practical situations. Distributed loads often refer to a type of load spread over a surface or a structure and can be modeled as continuous force per unit area.
For example, consider a bookshelf filled with books stacked vertically adjacent to each other. The weight of the books is evenly distributed over the length of the shelf. As a result, the pressure at different locations on the surface of the...
For example, consider a bookshelf filled with books stacked vertically adjacent to each other. The weight of the books is evenly distributed over the length of the shelf. As a result, the pressure at different locations on the surface of the...
967
Eccentric Loading
944
Eccentric loading is a crucial concept in the study of structural engineering and mechanics, particularly when analyzing the stability and stress distribution in columns. Unlike centric loading, where the force is applied along the centroidal axis, causing uniform compression, eccentric loading occurs when a force is applied off-center. This off-center application introduces not only direct compressive stress but also bending stress, significantly influencing the column's behavior under...
944
Bioavailability Enhancement: Drug Permeability Enhancement
197
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
197


