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Updated: Jan 29, 2026
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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
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FAPI Tracer:评估[68 Ga]Ga-DATA5m.SA.FAPi用于肺纤维化分子成像
Victoria Weissenböck1, Michaela Schlederer2, Latifa Bakiri3
1Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
概括
放射性标记的纤维细胞激活蛋白抑制剂 (FAPI) 显示出对肺纤维化成像的潜力. [68Ga]Ga-DATA5m.SA.FAPi的吸收在白血素诱导的纤维化中增加,支持其在分子成像中的使用.
科学领域:
- 放射化学 放射化学是指辐射化学.
- 分子成像学分子成像学
- 肺部医学 肺部医学
背景情况:
- 纤维细胞激活蛋白抑制剂 (FAPI) 正在成为纤维细胞疾病的有前途的成像剂.
- 肺纤维化是一种使人衰弱的疾病,诊断工具有限.
- [68Ga]Ga-DATA5m.SA.FAPi是一种新型的FAPI追踪器,可用于分子成像.
研究的目的:
- 评估[68Ga]Ga-DATA5m.SA.FAPi用于成像肺纤维化.
- 为了评估标记剂在白素诱导 (BLM) 和转基因 (fra-2tg) 鼠标模型中的有效性.
- 为了将成像发现与组织学和免疫组织化学分析相关联.
主要方法:
- 在BLM和fra-2tg小鼠模型中使用[68Ga]Ga-DATA5m.SA.FAPi的PET/CT扫描在各种疾病阶段.
- 活体生物分布研究.
- 组织学和免疫组织化学 (IHC) 分析以量化FAP表达.
主要成果:
- 肺部[68Ga]Ga-DATA5m.SA.FAPi吸收显示了BLM小鼠在5周后增加的趋势,由ex vivo分析 (p=0.0035) 证实.
- 在fra-2tg小鼠中没有检测到标记剂吸收的显著差异.
- 在早期BLM和轻度fra-2tg疾病阶段,IHC显示FAP表达升高,而在晚期BLM阶段,标记物吸收更为明显.
结论:
- [68Ga]Ga-DATA5m.SA.FAPi显示出作为肺纤维化分子成像剂的潜力,特别是在BLM模型中.
- 这项研究的结果补充了先前关于纤维性疾病的FAPI标记物的研究.
- 需要进一步的研究,以充分阐明FAPI标记剂在肺纤维化中的作用.
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