结合热量和色度分析作为检测假冒伟哥药片的工具®
Paweł Ramos1, Sławomir Wilczyński2, Klaudia Stocerz1,3
1Department of Community Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jedności 8b, 41-200 Sosnowiec, Poland.
Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
概括
假冒的Viagra®和暗网的西尔代纳菲尔片在质量和真实性方面表现出显著的变化. 结合热量和色度分析可以有效检测伪造的药物,突出非法药物购买的风险.
科学领域:
- 药品分析 药品分析
- 法医化学 法医化学
- 材料科学 材料科学 材料科学
背景情况:
- 对假冒药品的分析对公共健康和安全至关重要.
- 暗网对执法部门在控制非法毒品市场方面提出了重大挑战.
- 原始的伟哥 (西尔德纳菲尔酸盐) 是一种被广泛伪造的药物.
研究的目的:
- 为了比较分析原始Viagra®与来自暗网的西尔代纳菲尔片.
- 评估非法获取的西尔代纳菲尔的物理化学特性和真实性.
- 评估用于假冒药品检测的热和色度测量方法的有效性.
主要方法:
- 热重力测量 (TG),衍生热重力测量 (DTG) 和计算差异热分析 (c-DTA) 用于热稳定性和分解概况.
- 使用CIE L*a*b*系统进行色度分析以进行客观的视觉比较.
- 与原始Viagra®参考标准进行比较分析.
主要成果:
- 大多数暗网样本在热谱和颜色上表现出显著的变化,表明质量控制不佳.
- 只有少数样本 (V1,V3,V4,V6,V8) 与原始Viagra®有相似之处.
- 样本V2和V7显著偏离,表明可能没有或改变了西尔代纳菲尔的化学形式.
结论:
- 综合热量和色度分析对于识别假冒药品是有效的.
- 暗网样本中的物理化学不一致性凸显了与非法药物来源相关的风险.
- 该研究验证了用于检测伪造药物的综合分析技术的使用.
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