瘤学中的放射性标记FAPI放射性追踪剂:对当前诊断和新兴治疗应用的全面审查
Jolanta Czuczejko1,2, Bogdan Małkowski3, Jarosław Nuszkiewicz4
1Nuclear Medicine Department, Oncology Centre-Prof. Franciszek Łukaszczyk Memorial Hospital, 2 Dr I. Romanowskiej St., 85-796 Bydgoszcz, Poland.
Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
概括
纤维细胞激活蛋白抑制剂 (FAPI) 在诊断和治疗癌症方面表现有前途. 放射性标记的FAPI为成像和早期治疗效益提供了高瘤对比度,特别是在脱质瘤中.
科学领域:
- 在瘤学瘤学.
- 放射化学 放射化学是指辐射化学.
- 分子成像学分子成像学
背景情况:
- 纤维细胞激活蛋白 (FAP) 在上皮癌中在癌症相关纤维细胞 (CAF) 中高度表达.
- 在分子成像和放射性核酸治疗中,FAP是一个有前途的目标.
- 现有的审查缺乏针对FAP的诊断和治疗方法的全面综合.
研究的目的:
- 审查目前关于放射性核素标记的FAP抑制剂 (FAPI) 的证据.
- 强调FAPI的诊断实用性和新兴的治疗应用.
- 讨论影响FAPI生物行为的结构特征.
主要方法:
- 在PubMed,Scopus和Web of Science的结构化文献搜索.
- 专注于基于FAPI的成像和治疗.
- 诊断性能和治疗发展的综合.
主要成果:
- 在各种癌症中,FAPI射线追踪剂 ([68Ga]Ga, [18F]) 显示出高瘤与背景对比度.
- [18F]FDG PET/CT在病变明显性方面经常被FAPI PET/CT所超越.
- 治疗剂 ([177Lu]Lu-FAP-2286,[90Y]Y-FAPI-46, [225Ac]Ac-FAPI-04) 显示出瘤的保留,安全性和强大的抗瘤作用.
结论:
- 放射性标记的FAPI标记剂是潜在的双重诊断和治疗剂,用于脱质瘤.
- 临床证据还处于早期阶段,有关剂量测量和FAP表达变异性的问题.
- 对于theranostics,需要进一步开发FAPI构造和前性试验.
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