非编码RNA在神经退行性疾病中的不断扩大的作用:从生物标志物到治疗点
Xuezhi Zhao1, Yongquan Zheng2, Xiaoyu Cai3
1Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
概括
非编码RNA是神经退行性疾病 (如阿尔茨海默氏症和帕金森病) 中基因调节的关键. 它们显示出作为早期检测和新治疗点的生物标志物具有前途.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
背景情况:
- 非编码RNAs (ncRNAs) 是神经退行性疾病中关键的基因表达调节者.
- 微RNAs (miRNAs),长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs) 都与阿尔茨海默病 (AD),帕金森病 (PD) 和肌缩侧硬化症 (ALS) 有关.
研究的目的:
- 审查ncRNAs在神经退行性疾病病原发生中的作用.
- 评估ncRNAs作为早期检测和监测的生物标志物.
- 探索ncRNA向的治疗策略和提供挑战.
主要方法:
- 在AD,PD和ALS中对ncRNA的综合文献综述.
- 在突触功能,蛋白质稳定,线粒体生物学和神经炎症中分析ncRNA功能.
- 对ncRNA生物标记物的诊断平台和生物流体来源的评估.
- 对RNA向疗法的审查,包括反感性寡核酸和miRNA模仿剂/抑制剂.
- 评估用于目标识别的计算和多omics方法.
主要成果:
- ncRNAs显著影响病原蛋白聚合,神经元功能,神经炎症和血脑屏障完整性.
- 循环和基于组织的ncRNA显示出作为疾病诊断,监测和分层的生物标志物的潜力.
- 各种针对RNA的干预措施显示出希望,但交付和安全仍然是关键挑战.
- 计算和多学科方法正在推进目标优先级.
结论:
- 在神经退行性疾病中,ncRNAs代表了重要的诊断和治疗前沿.
- 克服生物异质性和交付障碍对于临床翻译至关重要.
- 跨学科的合作和严格的临床验证对于推进ncRNA研究至关重要.
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