管理IBD相关风险的微生物驱动策略:从感染到心理健康
Patrycja Krynicka1, Pablo Cortegoso Valdivia2,3,4, Maciej Morawski5
1Department of Gastroenterology and Nutrition Disorders, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Bydgoszcz, Poland.
Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
概括
炎症性肠病 (IBD) 是一种与肠道微生物群变化相关的全身免疫代谢综合征. 新兴的疗法,如便微生物种移植 (FMT) 和后生物药物,为个性化IBD护理提供了潜力.
科学领域:
- 免疫代谢过程中的免疫代谢.
- 微生物组学 微生物组学
- 胃肠病学 胃肠病学
背景情况:
- 炎症性肠道疾病 (IBD) 越来越多地被视为系统性免疫代谢疾病,而不仅仅是胃肠道疾病.
- 包括病毒体在内的肠道微生物群起着至关重要的作用,减少的短链脂肪酸 (SCFA) 与致病过程有关.
- 微生物群失调有助于表皮屏障受损,免疫调节失调,感染风险增加,贫血,神经精神问题和肠外表现.
研究的目的:
- 审查肠道微生物群改变在IBD病原发生中的作用.
- 批判性地评估IBD的新兴微生物向治疗方法.
- 讨论临床翻译的障碍,并提出个性化IBD护理的未来框架.
主要方法:
- 对IBD和肠道微生物群的现有研究进行文献审查和批判性评估.
- 对新兴的微生物群向策略的分析:便微生物群移植 (FMT),活生物治疗产品 (LBPs) 和精密后生物.
- 讨论临床翻译挑战和IBD管理的未来方向.
主要成果:
- 微生物群失生症,以减少SCFA为特征,在IBD中损害了上皮屏障功能和免疫调节.
- 微生物群的变化增加了对复发性感染 (例如,Clostridioides difficile),贫血,神经精神病并发症和肠外表现的易感性.
- FMT,LBP和后生菌药物作为IBD常规免疫抑制疗法的辅助药物显示出希望.
结论:
- 肠道微生物群在IBD的系统性免疫代谢方面发挥着核心作用.
- 针对微生物群的治疗方法代表了IBD管理中的潜在范式转变.
- 专注于微生物群平衡的个性化,功能综合的护理对于长期IBD缓解至关重要.
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