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Updated: Jan 29, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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药物代谢和药理动学的数学建模:在体外是正确的,在体外并不总是有效的.

Leslie Z Benet1, Jasleen K Sodhi1

  • 1Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, CA 94143, USA.

Pharmaceuticals (Basel, Switzerland)
|January 28, 2026
PubMed
概括

本研究引入了一个新的药理动力学框架,使用适应的基尔霍夫定律,简化清除率和速率常数导出. 它强调了微分方程在体内药物处置的局限性,为临床数据解释提供了模型独立的方法.

关键词:
基尔赫霍夫的定律 基尔赫霍夫的定律生物可用性 生物可用性不同方程 微分方程 微分方程药物代谢 药物代谢肝脏清除的时间平均居住时间.药物动力学 药物动力学通过脏清除.

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