协生菌在缓解功能性便秘的有效性和机制:通过代代时间优化
Linlin Wang1,2,3, Huahao Cai1,2,3, Qingwei Yao3
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
Nutrients
|January 28, 2026
概括
一种新型的基代时间 (GT) 引导的共生方法精确地将益生菌和益生菌配对用于功能性便秘 (FC). 这一策略通过促进有益细菌和改善便水分来增强肠道健康,提供了一个有前途的治疗方向.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 功能性便秘 (FC) 影响了中国8.5%的人口,经常与焦虑和抑郁症并发,降低了生活质量.
- 目前针对FC的益生菌-益生菌疗法缺乏菌株特定的优化,导致次优的协同效应.
- 微生态干预需要精确的配方,以提高治疗疗效,在管理胃肠道疾病.
研究的目的:
- 开发和验证一个以代代时间 (GT) 为指导的精密配对策略,用于制定优化的协生菌来治疗功能性便秘 (FC).
- 在便秘的临床前模型中,研究GT优化协生菌与单个益生菌或益生菌相比的协同效应.
- 阐明GT引导的共生疗法的潜在机制,包括对肠道微生物群,神经递质和肠道屏障功能的影响.
主要方法:
- 测量了四种益生菌菌株在八种寡糖体中的生成时间 (GT),以确定最佳的益生菌基质.
- 制定了一种GT优化的协生菌,并在洛佩拉胺诱导的小鼠便秘模型中评估其有效性.
- 使用16S rDNA测序,向代谢和定量PCR (qPCR) 评估机械效应,以分析肠道微生物群组成,代谢概况和基因表达.
主要成果:
- 与单个益生菌或益生菌治疗相比,GT优化的协生菌显示出明显优异的疗效.
- 同生菌治疗显著减少了第一个黑色便的时间,增加了便中的水含量,缓解了便秘.
- 机械学研究显示,结肠神经递质平衡恢复,水素表达抑制,酸盐生产细菌的丰富,以及肠道屏障完整性的修复.
结论:
- 一个GT指导的精密配对策略提供了一种新的方法,通过将益生菌菌株与理想的益生菌基质相匹配,优化功能性便秘 (FC) 的协生菌配方.
- 这一策略协同增强短链脂肪酸 (SCFA) 生产,肠道神经递质信号传递和水介导的水运输,从而改善便水分和加速肠道运输.
- 在临床前模型中,GT引导的共生方法显示出显著的前景,并为管理FC的人类临床试验中进一步调查提供了理由.
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