相关实验视频

Updated: Jan 29, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

植物化学品对动脉样硬化的影响:基于肠肝轴

Yiming Wang¹, Weiwei Cui¹

¹Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun 130021, China.

|January 28, 2026

概括

来自植物的植物化学物质可以通过积极影响肠肝轴来对抗动脉样硬化. 它们调节肠道微生物群并减少炎症,为心血管健康提供了一种新的治疗方法.

科学领域:

* 综合生物学和综合医学
* 营养科学和药理学

背景情况:

*动脉样硬化 (AS) 是心血管和脑血管事件的主要原因,与脂质不良和慢性炎症密切相关.
* 肠肝轴在AS病变发生过程中发挥着至关重要的作用,通过连接肠道微生物群,肝脏代谢和全身炎症.
* 针对AS肠肝轴的植物化学物质的治疗机制需要系统的总结.

研究的目的:

* 审查和综合植物化学干预通过肠肝轴影响动脉样硬化的机制.
* 探索植物化学物质,肠道微生物群,肝功能和AS发展之间的相互作用.

主要方法:

* 在PubMed,Web of Science和Embase进行了系统的文献搜索.
*关键词包括"植物化学物质"",动脉样硬化"",肠肝轴"",肠道微生物群"和"TMAO".
*采用叙事审查方法来综合有关作用途径和分子机制的证据.

主要成果:

* 植物化学物质,尽管生物利用率低,但被肠道微生物群代谢,影响肠-肝轴.
* 机制包括调节肠道微生物群,增强肠道屏障功能,调节胆酸代谢,并提供抗炎和抗氧化作用.
* 这些作用缓解脂质疾病,减少全身炎症,并对抗AS的进展.

结论:

*植物化学物质显示出通过肠肝轴干预动脉样硬化进展的潜力.
*需要进一步的研究来确定剂量反应关系和最佳治疗策略的临床疗效.

关键词:

这就是TMAOO.动脉样硬化动脉样硬化胆酸新陈代谢胆酸新陈代谢肠 - 肝轴肠 - 肝轴植物化学品植物化学品

更多相关视频

An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products

An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products

Published on: October 20, 2018

Author Spotlight: Development and Challenges of Feeding Assays for Insect Pest Management

Author Spotlight: Development and Challenges of Feeding Assays for Insect Pest Management

Published on: May 26, 2023

相关概念视频

Hypothalamic-Pituitary Axis

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

Perpendicular-Axis Theorem

Perpendicular-Axis Theorem

The perpendicular-axis theorem states that the moment of inertia of a planar object about an axis perpendicular to its plane is equal to the sum of the moments of inertia about two mutually perpendicular concurrent axes lying in the plane of the body.
Consider a circular disc of mass M and radius R lying along an x-y plane. The origin lies at the center of the disc, and the z-axis is perpendicular to the disc's plane. All three axes coincide at the disc's center. The moment of inertia of this...

Parallel-axis Theorem

Parallel-axis Theorem

The parallel-axis theorem provides a convenient and quick method of finding the moment of inertia of an object about an axis parallel to the axis passing through its center of mass. Consider a thin rod as an example. There is a striking similarity between the process of finding the moment of inertia of a thin rod about an axis through its middle, where the center of mass lies, and about an axis through its end using the conventional method. In the conventional method, the concept of linear mass...

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...