通过补充微生物组调制,N-乙糖胺和免疫球蛋白加强肠道屏障的完整性
Emma De Beul1, Jasmine Heyse1, Michael Jurgelewicz2,3
1Cryptobiotix SA, Technologiepark-Zwijnaarde 82, 9052 Ghent, Belgium.
Nutrients
|January 28, 2026
概括
血清衍生牛免疫球蛋白 (SBI) 和N-乙葡萄糖胺 (NAG) 显著改善了肠道屏障的完整性. 它们的结合表明了协同作用,增强了微生物多样性和短链脂肪酸生产,有利于肠道健康.
科学领域:
- 微生物组研究的研究.
- 肠道健康和屏障功能.
- 营养免疫学 营养免疫学
背景情况:
- 肠道屏障功能障碍和失生症是慢性胃肠道疾病的关键特征.
- 研究生物活性物质的协同效应对于新的治疗策略至关重要.
- 血清衍生牛免疫球蛋白 (SBI) 和N-乙葡萄糖胺 (NAG) 是肠道健康调节的潜在候选者.
研究的目的:
- 评估SBI和NAG对肠道微生物群和屏障完整性的单独和联合影响.
- 了解SBI和NAG对微生物组成和代谢物产生的影响.
- 探索SBI和NAG结合用于管理肠道疾病的潜力.
主要方法:
- 使用了ex vivo SIFR®技术与成年人类微生物群.
- 采用了Caco-2/THP-1上皮和免疫细胞的共同培养模型.
- 通过体电阻 (TEER) 评估肠道屏障的完整性.
主要成果:
- SBI和NAG分别提高了21%和29%的肠道屏障完整性.
- 这种组合 (SBI_NAG) 显示屏障完整性提高了36%.
- SBI和NAG诱导了明显的微生物转移,增加了酸和酸衍生物 (SBI) 或酸和丁酸盐 (NAG).
- SBI_NAG组合增强了所有三种短链脂肪酸 (SCFA),并增加了微生物多样性.
结论:
- SBI和NAG对肠道微生物群和屏障功能产生互补的影响.
- SBI和NAG的组合提供了一种新陈代谢平衡的方法来支持肠道健康.
- 结合SBI和NAG对患有肠道屏障损伤或失能症的人来说是有前途的.
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