用B族维生素调节单碳代谢,以保护视网膜屏障并防止视网膜退化
Hossameldin Abouhish1,2, Lamiaa Shalaby1, Omar Elzayat1
1Eye Research Institute, Oakland University, Rochester, MI 48309, USA.
Nutrients
|January 28, 2026
概括
维生素B缺乏会破坏视网膜屏障的完整性,因为它会损害同型半素的新陈代谢. 补充B族维生素 (B6,B9,B12) 可以恢复屏障功能,可能预防衰老的视网膜疾病.
科学领域:
- 眼科医生 眼科 眼科
- 营养科学 营养科学
- 血管生物学 血管生物学
背景情况:
- 维生素B12缺乏与血管和神经退行性衰老疾病有关.
- 缺陷会扰乱单碳代谢,提高同型半氨酸 (Hcy) 和风险血管功能障碍.
- 升高的Hcy与衰老的视网膜疾病和视网膜屏障 (BRB) 功能障碍有关.
研究的目的:
- 研究B族维生素缺乏如何影响单碳代谢和Hcy水平.
- 为了确定恢复B族维生素是否可以预防或治疗BRB功能障碍.
- 评估B族维生素水平对小鼠视网膜血管完整性的影响.
主要方法:
- 小鼠 (WT和cbs+/-) 被食缺乏或富含B族维生素 (B6,B9,B12) 的饮食.
- 测量血清B12水平和血Hcy以确认饮食影响.
- 通过光素血管学,OCT和视网膜白蛋白/紧密结合蛋白分析来评估BRB完整性.
主要成果:
- 缺乏维生素B显著降低血清B12和增加血Hcy.
- 这导致了BRB的破坏,包括血管泄漏和视网膜厚度的改变.
- 补充维生素B可以逆转这些有害影响,恢复BRB完整性.
结论:
- 长期缺乏维生素B6,B9和B12会破坏BRB.
- 补充B族维生素可以逆转BRB干扰并保持视网膜健康.
- 适当的B族维生素水平对于预防与BRB功能障碍相关的衰老视网膜疾病至关重要.
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