视眼患者维生素D缺乏与系统性结果之间的关联:现实世界队列研究
Shan-Shy Wen1, Chien-Lin Lu2,3, Ming-Ling Tsai4
1Graduate Institute of Applied Sciences and Engineering, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
Nutrients
|January 28, 2026
概括
玻璃眼患者的维生素D缺乏与死亡和心脏和脏问题的风险增加有关. 这突出了维生素D的状态,作为一种潜在的标志物,用于系统脆弱性在绿眼病患者.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
背景情况:
- 玻璃眼是一种视神经病变,经常与全身性疾病同时发生.
- 维生素D缺乏 (VDD) 与心血管和脏疾病有关,但其在青光眼结局中的作用尚不清楚.
研究的目的:
- 为了研究基线维生素D状态与初级绿眼病患者的长期系统性结果之间的关联.
- 评估VDD对该人口的死亡率和心脏病发作事件的影响.
主要方法:
- 使用电子健康记录进行的回顾性队列研究 (TriNetX美国协作网络).
- 包括患有初级青光眼和血清25-氧维生素D (25(OH) D水平的成年人 (≥18岁).
- 11,855名患有VDD (<30 ng/mL) 患者的倾向性得分匹配 (1:1) 与维生素D充足度 (VDA;≥30 ng/mL) 相比.
- 随访时间长达5年,评估所有原因死亡率,MACE,AKI和功能下降.
主要成果:
- VDD与所有原因死亡率 (HR 1.104),MACE (HR 1.151) 和AKI (HR 1.154) 的5年风险显著增加.
- 在VDD和VDA组之间没有观察到功能下降风险的显著差异 (HR 0.972).
- 风险差异在第一年出现,并在5年的随访期间持续存在.
结论:
- 初级玻璃眼患者的维生素D缺乏与死亡率和心脏病并发症的长期风险增加有关.
- 在这个队列中,VDD与功能下降无关.
- 维生素D的状况可以作为更广泛的系统性脆弱性的指标.
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