2型糖尿病患者肌肉质量和GNRI之间的关联
Shinta Yamamoto1, Yoshitaka Hashimoto1,2, Fuyuko Takahashi1
1Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Nutrients
|January 28, 2026
概括
老年营养风险指数 (GNRI) 与2型糖尿病 (T2D) 的肌肉质量相反相关. 然而,BMI调整后的GNRI残留物显示出正相关性,这表明营养状况会影响T2D的肌肉功能.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 2型糖尿病 (T2D) 与骨肌肉强度和质量降低有关.
- 营养不良是已知的肌肉质量下降的原因之一,但其与T2D老年营养风险指数 (GNRI) 的联系尚不清楚.
研究的目的:
- 调查GNRI与T2D患者骨肌质量之间的关联.
- 探索BMI对GNRI和肌肉质量之间的关系的影响.
主要方法:
- 从KAMOGAWA-A队列中对743名T2D参与者的横截面研究.
- 肌肉质量被评估为手握强度除以手臂肌肉质量.
- 多重线性回归用于分析GNRI和BMI调整后的GNRI残余与肌肉质量.
主要成果:
- 总的来说,GNRI与肌肉质量有相反的关联 (β = -0.17,p < 0.001).
- 经BMI调整的GNRI残留物显示出与肌肉质量 (β = 0.13,p < 0.001) 有显著的积极关联,特别是在男性和年轻人中.
- 关联因年龄,性别和血糖控制而有所不同.
结论:
- 在T2D中,GNRI与肌肉质量相反相关,但这种关系被BMI所混.
- 经BMI调整的GNRI残留物显示出一致的正相关性,表明营养状况可能支持T2D的肌肉功能.
- 改善营养状况可以提高T2D患者的肌肉功能.
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