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之前的过敏反应是否能确定接受牛奶和蛋口服食物挑战的患者之间的差异?

Liliana Klim¹, Maria Michalik¹, Paweł Wąsowicz²

¹SSG at Children's Diseases Clinic, Children's University Hospital, Jagiellonian University Medical College, 31-008 Krakow, Poland.

|January 28, 2026

概括

口服食物挑战 (OFCs) 证实了食物过敏,但先前的过敏反应对结果的影响不同. 亚托皮炎和喘预测OFC失败,特定的IgE水平根据过敏反应史而有所不同.

科学领域:

儿科过敏和免疫学
在食物过敏中临床决策
食物过敏的诊断准确性食物过敏的诊断准确性

背景情况:

口服食物挑战 (OFC) 是诊断食物过敏的黄金标准.
以往过敏反应史对OFC结局的影响尚不清楚.
之前的研究将过敏反应视为一般风险因素,而不是基于过敏反应史来探索不同的预测者概况.

研究的目的:

为了确定儿童患者OFC失败的预测因素.
根据对被挑战的食物有或没有先前过敏反应史的存在来分层预测因素.
在有过敏反应史和没有过敏反应史的儿童之间比较OFC衰竭的风险因素概况.

主要方法:

对于牛奶蛋白 (CMP) 和蛋白蛋白 (HEWP) 的儿科OFC的回顾性分析.
患者被分为有或没有过敏反应对特定食物的病史的组.
后勤回归和ROC分析被用来评估预测因素,如并发症和特定IgE (sIgE) 度.

主要成果:

在192个儿科OFC中,186个有有效结果;整体失败率为32.3%.
在没有先前过敏反应的儿童中,亚托皮炎预测了OFC失败;在先前过敏反应的儿童中,喘是边缘预测因素.
素特异性IgE (sIgE) 在没有先前过敏反应的儿童中显示出OFC衰竭的最高诊断准确性 (AUC = 0.81).

结论:

过敏反应史影响OFC结果和挑战失败的风险因素概况.
亚托皮炎和喘是显著的预测因素,但它们的影响根据先前的过敏反应不同.
根据过敏反应史对患者进行分层对准确的风险评估和预测OFC成功至关重要.

关键词:

食物过敏食物过敏过敏反应的历史.口服食物挑战口服食物挑战有关风险因素的风险因素.针对特定的IgE.

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