长期的城市空气污染驱动多阶段神经精神疾病轨迹:一个前性队列研究
Yuanyuan Song1, Shiqing Zhang2,3,4, Siru Yang1
1School of Public Health, Guangzhou Medical University, Guangzhou 511436, China.
Toxics
|January 28, 2026
概括
长期暴露于细颗粒物 (PM2.5) 和氧化 (NOx) 等空气污染物,显著增加患神经精神疾病,特别是阿尔茨海默病的风险. 易受伤害的群体包括女性,年轻人和贫困人口.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 公共卫生流行病学 流行病学
背景情况:
- 神经精神疾病是一个日益严重的全球健康问题.
- 环境因素,特别是空气污染,越来越多地影响着它们的发展.
- 长期暴露于细颗粒物 (PM2.5) 和氧化 (NOx) 需要进一步调查神经精神疾病的进展.
研究的目的:
- 研究长期暴露于PM2.5和NOx与八种神经精神疾病的进展之间的关联.
- 分析神经精神疾病发展的不同轨迹阶段.
- 描述非线性暴露-反应关系,并确定易受伤害的子组.
主要方法:
- 使用502,356名参与者的英国生物库数据进行的前性队列研究.
- 多状态模型被用来分析神经精神疾病的三个轨迹阶段.
- 限制立方线 (RCS) 回归模型被用于评估非线性暴露-反应关系.
主要成果:
- 增加对PM2.5和NOx的暴露与初始过渡到情绪障碍 (第一阶段) 密切相关.
- 阿尔茨海默病在所有阶段都显示出与空气污染暴露的最一致和最高风险关联.
- 对于PM2.5和NOx的危险比率在进展阶段增加,女性,年轻人和社会经济贫困人口的风险增加.
结论:
- 长期暴露于PM2.5和NOx是神经精神疾病发展和进展的重要危险因素.
- 空气污染的影响因疾病类型和进展阶段而异,阿尔茨海默病特别容易受到影响.
- 空气污染应该被认为是预防神经精神疾病的可修改风险因素,针对弱势群体进行有针对性的干预.
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