氧化纳米粒子诱导的神经毒性:潜在的分子机制和未来的前景
Chun Chen1,2,3, Xingyao Pei2, Yonger Yu2
1State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Toxics
|January 28, 2026
概括
氧化纳米颗粒 (ZnO NPs) 可以通过各种途径进入中枢神经系统 (CNS) 损害大脑. 它们的神经毒性涉及氧化应激和炎症,可能增加神经退行性疾病的风险.
科学领域:
- 纳米技术纳米技术
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 氧化纳米颗粒 (ZnO NPs) 越来越多地用于消费,医疗和食品产品.
- 这种广泛使用引发了人们对其潜在的神经毒性和对中枢神经系统 (CNS) 的影响的担忧.
研究的目的:
- 审查ZnO NP进入中枢神经系统的途径.
- 总结ZnO NPs的神经毒性作用和分子机制.
- 讨论潜在的缓解策略和风险评估的必要性.
主要方法:
- 文献综述综合了关于ZnO NP神经毒性的当前研究.
- 对纳米粒子转移到中枢神经系统的机制的分析.
- 检查分子通路和细胞对ZnONP的反应.
主要成果:
- ZnO NPs通过血脑屏障,感觉神经和肠脑轴进入中枢神经系统.
- 暴露导致行为缺陷,大脑损伤,线粒体功能障碍,氧化应激,神经炎症和细胞死亡 (亡,铁亡,热亡).
- 神经毒性与NP特性 (大小,形状) 和Zn2+离子释放有关,可能促进Tau聚合和神经退行.
结论:
- 由于其多方面的机制,ZnO NP的神经毒性是一个重大问题.
- ZnO NPs的物理化学特性影响了它们的毒性.
- 进一步的研究和风险评估对于安全的应用至关重要,通过表面修饰和天然化合物进行潜在的缓解.
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