与环境相关度的微塑料和avermectin的同时暴露在幼虫和成年斑马鱼中通过ROS介导的MAPK信号引起严重的心脏损伤
Guanghua Xiong1,2, Min Lu1, Yaxuan Jiang1
1Key Laboratory of Embryo Development and Reproductive Regulation of Anhui Province, College of Biology and Food Engineering, Fuyang Normal University, Fuyang 236041, China.
Toxics
|January 28, 2026
概括
同时接触到阿维美克丁 (AVM) 和聚烯微塑料 (MP) 通过增加氧化应激和炎症,会损害斑马鱼的心脏. 抑制活性氧物种 (ROS) 和MAPK通路对这种毒性进行了部分保护.
科学领域:
- 环境毒理学环境毒理学
- 心血管毒理学心血管毒理学
- 生态毒理学 生态毒理学
背景情况:
- 聚乙烯微塑料 (PS-MPs) 和甲 (AVM) 是普遍存在的水污染物.
- 对于PS-MPs和AVM对心脏发育的联合毒性尚不清楚.
研究的目的:
- 研究AVM与两个大小的PS-MP (LMP和SMP) 在幼虫和成年斑马鱼中同时暴露的心脏毒性.
- 阐明毒性的潜在机制,重点关注氧化应激,炎症和信号通路.
主要方法:
- 斑马鱼暴露于AVM和PS-MPs (LMPs,20μm;SMPs,80nm) 中.
- 评估了心脏发育,存活率,细胞计数,抗氧化酶活性和炎症性细胞因子水平.
- 使用了组织病理学,转录组测序,生物信息学分析和药理学干预措施.
主要成果:
- 同时暴露导致幼虫的生存率,体长,化率和心肌细胞数量下降.
- 斑马鱼幼虫显示中性粒细胞,CAT和SOD活动减少,TNF-α和IL8增加.
- 成年斑马鱼表现出心肌细胞失调,间歇性,抑制增殖和增加亡.
- 转录组分析突出了氧化减少,炎症反应和MAPK信号通路的变化.
- 抑制ROS和阻断MAPK通路部分挽救了心脏损伤.
结论:
- 在斑马鱼中,AVM和PS-MPs的同时暴露会引起显著的心脏毒性.
- 毒性主要通过ROS依赖的MAPK信号通路进行介导.
- 这项研究强调了水生生态系统中微塑料和农药联合暴露的环境风险.
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