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评估聚乙烯纳米塑料诱导心脏毒性在不同的饮食模式下在小鼠
Shuyi Wang1, Tao Wu2, Jie Dai2
1School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China.
Toxics
|January 28, 2026
概括
饮食习惯显著恶化纳米塑料 (NP) 心脏毒性. 高脂肪和高果糖饮食加剧NP诱导的心脏炎症和纤维化,影响食品污染物的风险评估.
科学领域:
- 环境毒理学环境毒理学
- 心血管研究研究心血管研究
- 食品安全 食品安全
背景情况:
- 纳米塑料 (NP) 是新兴的食品传播污染物.
- 核可以在心脏中积累,并导致有毒效应.
- 饮食习惯对NP心脏毒性的影响尚不清楚.
研究的目的:
- 研究不同的饮食模式如何影响纳米塑料对心脏的毒性.
- 评估聚乙烯纳米塑料 (PS-NP) 在各种饮食下的小鼠中的分布和危险影响.
主要方法:
- 小鼠被养正常的,高脂肪 (HFD) 或高果糖 (HFrD) 的饮食和口服的PS-NP (80 nm).
- 方法包括光追踪,组织病理学,炎症/纤维细胞标志物量化和转录基因测序.
- 暴露持续时间为1,4周和8周.
主要成果:
- 在8周后,在HFD和HFrD小鼠的心脏中观察到显著的PS-NP积累.
- 在暴露于PS-NP的小鼠中,HFD和HFrD都加剧了心脏原体沉积和炎症.
- HFD暴露激活了MAPK信号,促进纤维化;HFrD暴露通过TNF信号通路放大了损伤.
结论:
- 饮食习惯显著加剧由食物传播纳米塑料引起的心脏毒性.
- 高脂肪和高果糖饮食会恶化NP诱导的心脏炎症和纤维化.
- 饮食模式对于评估食物污染物的风险至关重要,如纳米塑料.
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