重金属对男性下丘脑-垂体-质轴相关激素的年龄相关影响
Yayuan Mei1, Yongfu Yan2, Shenglan Ke3
1Big Data Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Toxics
|January 28, 2026
概括
暴露于重金属会影响男性荷尔蒙,特别是在青少年和老年人中. 维生素D和叶酸可能会改变这些效应,其中涉及PI3K-Akt通路.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 重金属对男性下丘脑-垂体-丸 (HPT) 轴的影响尚不清楚.
- 男性的荷尔蒙调节对于生殖健康和整体健康至关重要.
研究的目的:
- 调查男性暴露于特定重金属和HPT轴相关激素之间的关联.
- 探索重金属对男性激素的潜在剂量反应关系和混合物影响.
- 检查维生素D和叶酸的修饰作用,并确定潜在的生物途径.
主要方法:
- 来自对6547名年龄在3至80岁之间的男性进行全国代表性调查的数据分析.
- 测量五种金属和十二种性激素.
- 应用多变量线性回归,受限立方线和基于量子的g计算用于统计分析.
- 包括叙事审查和生物信息学分析来探索机制.
主要成果:
- 暴露于重金属与激素变化有关,特别是在青少年和老年成年男性中.
- 具体的荷尔蒙效应在青少年中从-5.10%到18.12%,在老年男性中从3.17%到10.94%不等.
- 维生素D改变了儿童/青少年的效果,以及所有年龄段的叶酸.
- 确定PI3K-Akt信号通路作为一个潜在的机制.
结论:
- 暴露于重金属与男性荷尔蒙乱有关,在各个年龄组的影响各不相同.
- 维生素D和叶酸在调节这些重金属诱导的荷尔蒙变化方面发挥着作用.
- PI3K-Akt路径代表了重金属和男性激素干扰之间的潜在机械联系.
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