2008-2024年在莫斯科从野中分离出来的阿维拉病毒的分子表征
Anastasia Treshchalina1, Elizaveta Boravleva1, Daria Gordeeva1
1Chumakov Federal Scientific Center for the Research and Development of Immune-and-Biological Products, Village of Institute of Poliomyelitis, Settlement "Moskovskiy", 108819 Moscow, Russia.
Veterinary sciences
|January 28, 2026
概括
野生水鸟,包括鸟,可以传播鸟类类类型的帕拉米克索病毒,如纽卡斯尔病病毒 (AOAV-1) 和APMV-4. 在莫斯科发现的分离物是非致病的,这表明在迁移期间的风险很低.
科学领域:
- 鸟类病毒学 鸟类病毒学
- 野生动物流行病学
- 分子遗传学分子遗传学
背景情况:
- 禽类帕拉米克索病毒 (APMV) 是家禽和野生鸟类的重要病原体.
- 野生水鸟是众所周知的各种APMV菌株的长途传播者.
- 关于野生鸟种群中APMV的多样性和病原性存在有限的数据.
研究的目的:
- 评估秋季迁徙期间鱼中APMV的生物多样性和潜在风险.
- 确定和描述在莫斯科和莫斯科地区野生水鸟群中流传的APMV菌株.
- 根据分子标记物评估分离的APMV菌株的致病性.
主要方法:
- 从2008年到2024年,收集和分析了3604个大毛的便样本.
- 隔离和部分测序1 (AOAV-1) 和4 (APMV-4) 的鸟类形病毒.
- 单独病毒的基因分析和F蛋白分裂部位基因分析.
主要成果:
- 确定了四个AOAV-1和九个APMV-4隔离物.
- AOAV-1分离物属于1型基因组 (II类),APMV-4分离物属于1型基因组的欧亚亚亚亚亚基因组.
- 所有的分离物都具有F蛋白分裂部位的模式,与lentogenic和non-pathogenic菌株一致.
结论:
- 莫斯科和莫斯科地区的鱼有遗传多样化的APMV,包括AOAV-1和APMV-4.
- 鉴定到的分离物具有分子性质的非致病特征,这表明在迁移期间严重疾病传播的风险很低.
- 对野生鸟群中APMV的持续监测对于早期检测和预防潜在的疫情至关重要.
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