减少马类角膜SCC的复发:辅助西斯普拉丁生物降解珠子疗法的结果
Amy Dagenais1,2,3, Tristan Juette3, Marie-Odile Benoit-Biancamano2,3
1Centre Hospitalier Universitaire Vétérinaire, Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, 3200 Sicotte St., St-Hyacinthe, QC J2S 8H5, Canada.
辅助的西斯生物降解珠 (CBBs) 显著降低了角膜和四肢的马状细胞癌 (SCC) 的复发率. 大多数不良反应是轻微的,并在两个月内消失,表明CBBs被人很好地容忍.
科学领域:
- 兽医眼科医生 兽医眼科医生
- 马类瘤学 马类瘤学
- 手术瘤学手术瘤学
背景情况:
- 状细胞癌 (SCC) 是马中最常见的眼睛瘤.
- 仅仅针对马类皮角性SCC的手术治疗就有45%的高复发率.
研究的目的:
- 评估西斯生物降解珠 (CBBs) 的疗效,作为对马类角膜性SCC手术的辅助.
- 在眼部SCC的马中记录与CBBs相关的不良影响.
主要方法:
- 对17匹马进行了回顾性研究,其中17匹马具有经遗传病理学证实的角膜SCC.
- 手术切除 (角切除术/结节切除术),然后植入CBBs.
- 手术后的监测时间长达五年.
主要成果:
- 当地复发率在一年内为17.64%,在两年内为8.33%.
- 轻微的不良反应 (化学反应,高血压,变色,颗粒状组织) 是常见的,但在1-2个月内消失.
- 两匹马患有珠子相关的脑膜炎;除了一例外,所有的视力都被保留了.
结论:
- 辅助CBB可能会显著降低马类角质内皮SCC的复发率.
- 治疗一般耐受良好,副作用可控.
- CBBs代表了一种有前途的治疗选择,用于马眼部SCC.
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