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在EECA国家的艾滋病毒患者中,C型肝炎病毒的遗传多样性
Vasiliy E Ekushov1, Maksim R Halikov1, Irina P Osipova1
1State Research Center of Virology and Biotechnology VECTOR, 630559 Koltsovo, Russia.
Viruses
|January 28, 2026
概括
在亚美尼亚,吉尔吉斯斯坦和俄罗斯的HIV联合感染个体中分析了C型肝炎病毒 (HCV) 的遗传多样性. 3a亚型占主导地位,新亚型出现,表明共享的传播途径,特别是在注射毒品 (PWID) 的人群中.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 使用直接作用抗病毒药物 (DAA) 消除C型肝炎病毒 (HCV) 的全球努力需要了解病毒遗传多样性.
- 对HCV的遗传特征对于追踪传播至关重要,特别是在易受感染的人群中,如艾滋病毒感染者.
研究的目的:
- 确定亚美尼亚,吉尔吉斯斯坦和俄罗斯克拉斯诺亚尔斯克地区的艾滋病毒共感染个体中HCV的分子遗传多样性.
- 在这些关键人群中识别主导的HCV亚型和新的遗传变异.
主要方法:
- 在2021-2023年间对来自艾滋病毒/HCV同时感染患者的Core/E1基因片段 (亚美尼亚n=73,吉尔吉斯斯坦n=180,克拉斯诺亚尔斯克州n=141) 的遗传学分析.
- 使用最大概率方法来构建家族遗传树.
- 数据收集发生在各自地区的艾滋病中心.
主要成果:
- 在亚美尼亚 (56.2%) 和吉尔吉斯斯坦 (51.4%) 的HCV亚型3a占主导地位.
- 亚美尼亚首次发现HCV亚型4a.
- 在吉尔吉斯斯坦,新发现的HCV基因型2,包括三个亚型.
- 遗传学分析揭示了明显的HCV集群,表明了常见的传播途径,特别是在注射毒品的人 (PWID) 中.
结论:
- 在亚美尼亚,吉尔吉斯斯坦和克拉斯诺亚尔斯克州的艾滋病毒共感染人口中存在显著的HCV遗传多样性.
- 新亚型和共享传播集群的出现突显了综合预防和治疗策略的必要性.
- 研究结果表明,这些国家之间和这些国家内部存在相互连接的HCV传播网络,这强调了区域监测的重要性.
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