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相关概念视频

What is Variation?01:14

What is Variation?

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Apart from the measures of central tendency, distribution, outliers, and the changing characteristics of data with time, an important characteristic of any data set is its variation or spread. In some data sets, the data values are concentrated closely near the mean; in others, the data values are more widely spread out from the mean.
The range, standard deviation, standard error, and variance are the different measures of variation.
Range: The range is the difference between its maximum and...
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Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

6.8K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
6.8K
Review and Preview01:10

Review and Preview

8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

11.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
Variation01:19

Variation

8.0K
An important characteristic of any set of data is the variation in the data. In some data sets, the data values are concentrated closely near the mean; in other data sets, the data values are more widely spread out from the mean. The most common measure of variation, or spread, is the standard deviation, which is the square root of variance.
When independent and dependent variables are plotted on a scatter plot, the slope of a line is a value that describes the rate of change between the two...
8.0K
Variation of Atmospheric Pressure01:18

Variation of Atmospheric Pressure

4.1K
Change in atmospheric pressure with height is particularly interesting. The decrease in atmospheric pressure with increasing altitude is due to the decreasing gravitational force per unit area as we move away from the surface of the earth.
Assuming the air temperature is constant at a given altitude and that the ideal gas law of thermodynamics describes the atmosphere to a good approximation, one can find the variation of atmospheric pressure with height.
Let p(y) be the atmospheric pressure at...
4.1K

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相关实验视频

Updated: Jan 29, 2026

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
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Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

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肠道病毒D68序列变异和致病性:一篇综述

Yi Zhu1, Liting Wang1, Jun Shen1

  • 1Infectious Disease Department, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.

Viruses
|January 28, 2026
PubMed
概括

肠道病毒D68 (EV-D68) 的基因组变异影响其引起严重疾病和疫情的能力. 在像VP1这样的关键地区监测突变对于预测和为未来的流行病做好准备至关重要.

科学领域:

  • 病毒学 病毒学
  • 基因组学就是基因组学.
  • 流行病学 流行病学

背景情况:

  • 肠道病毒D68 (EV-D68) 是一种神经向性呼吸道病毒,与儿科急性软性脑膜炎 (AFM) 和严重呼吸道疾病有关.
  • 自2014年以来发现的EV-D68的反复流行,凸显了了解其毒性因素的必要性.
  • 基因组决定因素通过影响宿主相互作用,免疫逃避和复制来显著改变EV-D68的致病性.

研究的目的:

  • 系统地审查那些增强EV-D68毒性的基因组部位.
  • 专注于关键区域:VP1受体结合部位,2Apro/TRAF3分裂部位,3Cpro免疫调节区域.
  • 建议监测疫情爆发准备的关键毒性决定因素.

主要方法:

  • 对EV-D68.8的基因组变异进行系统的文献综述.
  • 在VP1,2Apro/TRAF3和3Cpro区域的突变分析.
  • 序列变异与宿主受体相互作用,免疫逃避和复制效率的相关性.

主要成果:

  • 在VP1位点的突变改变了对宿主受体 (酸,硫酸,MFSD6) 的亲和力,影响病毒的进入和热带性.
  • 2Apro/TRAF3分裂部位的变化可能会通过损害TRAF3分裂来减少免疫逃避,从而降低病原性.
关键词:
肠道病毒 D68 的病毒.基因组变化的基因组变化.非结构性蛋白质的结构.病原性是一种病原性.结构性蛋白质是一种结构性蛋白质.

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  • 3Cpro区域的变异通过影响参与翻译和自的宿主蛋白质的分裂来调节病毒复制和抗病毒反应.
  • 结论:

    • 特定的基因组部位,包括VP1,2Apro/TRAF3和3Cpro,对于EV-D68的毒性至关重要.
    • 监测这些地区的突变,特别是表面暴露的VP1,对于有效的疫情准备是必不可少的.
    • 了解EV-D68病毒性的基因组决定因素可以改善管理和预防流行病的策略.