氧化鼻喷雾 (NONS) 对SARS-CoV-2变种和主要呼吸道病毒的广泛杀菌活性
James Martins1, Selvarani Vimalanathan2, Jeremy Road3
1SaNOtize Research & Development Corp., Vancouver, BC V6P 6T3, Canada.
Viruses
|January 28, 2026
概括
一种氧化鼻喷雾剂 (NONS) 显示出对主要呼吸道病毒的快速,广泛的杀毒活性. 这种具有广泛作用的抗病毒策略显示了对流行病准备和季节性使用针对SARS-CoV-2和流感等病毒的潜力.
科学领域:
- 病毒学 病毒学
- 抗病毒研究 抗病毒研究
- 公共卫生 公共卫生
背景情况:
- 像SARS-CoV-2,流感和RSV这样的呼吸道病毒导致全球显著的发病率.
- 有限的治疗选择和缺乏疫苗需要广泛的抗病毒策略,独立于病原体.
- 氧化 (NO) 通过包括S-化在内的氧化还原机制具有抗病毒特性.
研究的目的:
- 评估一氧化鼻喷雾剂 (NONS) 对各种呼吸道病毒组的体外杀菌效果.
- 确定对临床相关的病毒病原体NONS活性的速度和频谱.
- 评估NONS作为流行病准备和季节性呼吸道病毒控制工具的潜力.
主要方法:
- 病毒悬浮剂 (大约1个小时) 10^4 CCID50) 被暴露在NONS中,在室温下接触时间为5秒至2分钟.
- 在中和后使用终点稀释试验量化了残留病毒感染性.
- 这项研究包括SARS-CoV-2变种,流感A和B,RSV,hMPV,HPIV-3和人类犀牛病毒14.
主要成果:
- 在所有测试的病毒中,NONS迅速降低了病毒感染力,在2分钟内实现了>3 log10的减少.
- 在30秒至2分钟内,SARS-CoV-2变种 (Alpha到XBB 2.0) 被禁用到无法检测的水平.
- 流感病毒显示出快速无活化 (在10-15秒内),而RSV,hMPV,HPIV-3和rhinovirus 14则在1-2分钟内无活化.
结论:
- NONS对广泛的呼吸道病毒具有快速和广泛的杀毒活性.
- 这些发现支持NONS在流行病准备策略中的潜在实用性.
- 此外,NONS也可以作为一种有价值的工具来管理季节性呼吸道病毒感染.
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