接种SARS-CoV-2疫苗后的甲状腺眼病:一个病例系列的经验
Alin Abreu Lomba1,2, María Elena Tello-Cajiao2, Mónica Morales1
1Endocrinology Department, Clínica Imbanaco Grupo QuirónSalud, Cali 760042, Colombia.
Vaccines
|January 28, 2026
概括
这一案例系列表明,在患有自身免疫性甲状腺疾病的患者中,COVID-19疫苗接种和甲状腺眼病 (TED) 之间存在联系. 临床医生应监测疫苗接种后的眼睛和甲状腺症状.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺眼病 (TED) 是格雷夫斯病的常见表现,在SARS-CoV-2疫苗接种后很少报告.
- 在接种COVID-19疫苗后观察到自身免疫性甲状腺疾病.
研究的目的:
- 为了展示COVID-19疫苗接种后发生的TED案例系列.
- 提供关于这种潜在安全信号的临床数据.
主要方法:
- 五位女性的回顾案例系列,他们开发了TED后COVID-19疫苗接种.
- 分析了临床表现,TED严重程度 (ETA/EUGOGO),实验室发现和成像.
- 评估了用皮质类固醇,和Levothyroxine调整治疗结果.
主要成果:
- 五名女性 (平均年龄47岁) 在mRNA或腺病毒载体COVID-19疫苗接种3-20天后开发了TED.
- 症状包括眼睛疼痛,外眼,头痛和喉;严重程度从轻度到严重.
- 治疗导致甲状腺功能和炎症在3个月内得到改善.
结论:
- 在患有自身免疫性甲状腺疾病的个体中,COVID-19疫苗接种和新发病或恶化的TED之间存在时间关联.
- 虽然接种疫苗的好处是显著的,但对免疫接种后的眼睛和甲状腺症状的警对于及时诊断和管理至关重要.
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