在LEEP之后的HPV疫苗接种和HPV结果:来自北挪威的回顾性基于人口的队列研究,2022-2024年
Sveinung Wergeland Sørbye1, Mona Antonsen1, Elin Richardsen1,2
1Department of Clinical Pathology, University Hospital of North Norway, 9006 Tromsø, Norway.
Vaccines
|January 28, 2026
概括
接种HPV疫苗与在高度宫内皮瘤瘤 (CIN2+) 循环电外科切除手术 (LEEP) 后检测HPV风险降低有关. 这一发现表明,接种疫苗可能会改善接受LEEP治疗的妇女的结果.
科学领域:
- 妇科瘤学 妇科瘤学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 用循环电外科切除手术 (LEEP) 治疗高度宫内皮质瘤 (CIN2+) 的妇女面临人类乳头瘤病毒 (HPV) 检测的持续风险.
- 了解缓解LEEP后HPV阳性因素对于改善患者随访和结果至关重要.
研究的目的:
- 在LEEP后的第一个随访期间调查HPV疫苗接种和HPV阳性之间的关联.
- 评估HPV疫苗接种时间与LEEP治疗对HPV检测率的影响.
主要方法:
- 在挪威 (2022-2024) 接受LEEP治疗的1052名妇女 (20-79岁) 的回顾性基于人口的队列研究.
- 针对HPV疫苗接种情况,时间和疫苗类型,从国家免疫登记册中获取.
- 随访HPV状态 (总体,HPV16,HPV18,其他组合类型) 通过使用罗氏科巴斯4800测试来确定.
主要成果:
- 在第一次随访时,HPV阳性总体为31.3% (329/1052).
- 与未接种疫苗的妇女相比,接种疫苗的妇女的HPV阳性率明显较低 (24.7%),ARR为13.0pp (p=5.2x10^-6).
- 调整后的分析显示,在LEEP年度接种疫苗与随访HPV阳性风险降低有关 (aRR为0.592;p=0.000348).
结论:
- 在LEEP后的首次随访之前进行的HPV疫苗接种与HPV阳性降低有关.
- 虽然有希望,但HPV阳性是代用终点;需要进一步研究长期临床结果来证实这些发现.
关键词:
在HPV测试阳性测试的阳性.疫苗接种 疫苗接种 疫苗接种在HPV16中,HPV16是最重要的.在HPV18中,HPV18是最重要的.挪威 挪威 挪威 挪威 挪威宫内皮质瘤的发生.循环电外科切除手术 (LEEP) 是一种循环电外科切除手术.这是一项以人口为基础的研究.在治疗后进行后续监测.基于注册表的队列群是基于注册表的队列群.更多相关视频
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