针对肝脏疾病的疫苗接种策略:一个范围审查
Zahra Beyzaei1, Bita Geramizadeh1,2, Sara Karimzadeh3
1Transplant Research Center, Shiraz University of Medical Sciences, Shiraz 7193711351, Iran.
Vaccines
|January 28, 2026
概括
针对A,B和E型病毒性肝炎的疫苗是安全有效的,而B型肝炎的疫苗接种对于预防母婴传播至关重要. 针对免疫功能低下的个体和肝病患者需要有针对性的策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 病毒性肝炎是全球慢性肝病的主要原因之一.
- 有效的疫苗接种策略对于公共卫生至关重要.
- 本次审查侧重于有关疫苗安全性和有效性的最新证据.
研究的目的:
- 评估针对A,B,C和E型肝炎的疫苗的安全性和有效性.
- 评估特定人群的疫苗反应,包括患有慢性肝病或艾滋病毒感染的人群.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Scopus) 中进行全面的文献搜索.
- 包括2000年1月至2025年9月的英语语言学习.
- 选了5254个记录,其中166项研究符合纳入标准.
主要成果:
- 甲型肝炎疫苗显示出出色的安全性,高血清保护性和持久免疫力.
- 乙型肝炎疫苗表现出强烈的免疫性;新生儿疫苗预防传播,减少肝癌.
- 肝炎E疫苗在高血清转化率下是安全的;响应在特定人群中是减少的,但有意义的.
- 型肝炎疫苗没有获得许可,治疗性疫苗的疗效有限.
结论:
- 肝炎A,B和E疫苗是安全的,免疫的和有效的.
- 新生儿乙型肝炎疫苗接种对于预防母婴传播至关重要.
- 优化疫苗接种策略对于免疫功能低下的个体,移植接受者以及患有慢性肝脏或HCV感染的人来说至关重要.
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