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儿童系统性化物暴露的尿蛋白生物标志物
Nawapan Pongsapipatana1, Patcharaporn Gavila2, Sung-Dae Cho3
1Center of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand.
Ecotoxicology and environmental safety
|January 28, 2026
概括
儿童高化物暴露会破坏系统生理学,改变参与骨健康和组织发育的蛋白质. 这项研究强调了分子干扰对骨和牙健康的影响.
科学领域:
- 环境健康 环境健康
- 生物化学 生物化学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 最佳的化物水平对于口腔健康至关重要.
- 慢性高化物摄入会导致骨和牙化,特别是在儿童中.
- 过度化物暴露的全身生理效应和潜在机制尚不清楚.
研究的目的:
- 研究儿童因高化物暴露而引起的全身分子干扰.
- 通过尿蛋白质分析,识别受过多化物摄入影响的特定蛋白质.
- 探索这些分子变化对骨和软组织恒温的影响.
主要方法:
- 使用液体染色学-双重质谱法 (LC-MS/MS) 的比较性尿蛋白质组分析.
- 根据尿路化物分泌的情况,将学童分为高化物 (HF) 和低化物 (LF) 组.
- 尿蛋白质的量化和差异表达分析.
主要成果:
- 在460个量化蛋白质中,有10个蛋白质在HF组与LF组相比表达不同.
- 上调的蛋白质包括PHPT1,SPP1 (骨质),COLEC12,CST4,DCHS1和LDHB.
- 下调的蛋白质包括CTSH,NECTIN1,TNC (tenascin-C) 和KLK1.
- 基因实体学丰富表明细胞粘附,骨化和组织发育的改变.
- 在骨质松丁和田素-C中观察到显著的变化,这表明焦点粘附信号受损,矩阵完整性受损和生物矿物化的失调.
- 与质形成,氧化应激和免疫调节相关的蛋白质也发生了变化,这表明细胞外矩阵组织和炎症通路的广泛破坏.
结论:
- 过度的化物暴露在儿童中会导致显著的系统分子干扰.
- 观察到关键骨重塑蛋白质的变化表明骨和牙矩阵组织受损.
- 研究结果表明,可能会破坏细胞外基质完整性,生物矿物化和炎症通路.
- 这项研究强调了化物暴露对儿童健康的广泛生物学影响,并强调需要监测化物水平.
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