在2021/22年和2022/23年重复流感疫苗接种效果,在香港的社区基队列中
Jennifer C Zhong1, Shuyi Zhong1, Lisa Touyon2
1WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
The Journal of infectious diseases
|January 28, 2026
概括
随着时间的推移,每年接种流感疫苗可能会导致免疫反应较弱. 这项在香港的研究发现,重复接种疫苗减少了早期抗体的增强,但在六个月后对抗体水平的影响很小.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 每年重复接种流感疫苗与免疫反应和有效性降低有关.
- 以前的研究主要评估了疫苗接种后30天的免疫原性.
- 随着COVID-19的流行,我们有了一个独特的机会来研究疫苗的反应,而不是在香港同时流行的流感.
研究的目的:
- 调查每年重复接种流感疫苗对抗体标位增加和减少的影响.
- 在没有流感循环的情况下,分析两年 (2021/22和2022/23) 的抗体反应.
- 评估疫苗接种史对抗体动态的影响.
主要方法:
- 在香港进行的基于社区的队列研究.
- 用于测量对8种疫苗菌株的抗体标位的血液凝结抑制试验.
- 统计分析以估计疫苗接种率的增加,下降以及重复接种疫苗的影响.
主要成果:
- 在2022/23年与2021/22年相比,在2022/23年重复接种疫苗的人群中观察到疫苗接种后标位和平均倍增的差异.
- 较高的疫苗接种率与特定菌株的抗体减弱速度较慢相关 (A/Victoria/2570/2019,B/Phuket/3073/2013,B/Austria/1359417/2019).
- 尽管缓慢衰减,但吸收量较高的参与者在接种疫苗后六个月实现了类似的抗体标位.
结论:
- 重复接种流感疫苗与在接种疫苗后14天抗体标位增加的减少有关.
- 重复接种疫苗对抗体水平的影响在接种疫苗后六个月似乎变得不那么显著.
- 研究结果表明,随着时间的推移,重复接种疫苗对流感特异性免疫有微妙的影响.
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