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使用新型冷却激光装置治疗前列腺癌的焦点治疗:早期试验结果
Jonathan Kam1,2,3, Bishoy Hanna1, Stuart Jackson1
1Nepean Urology Research Group, Kingswood, New South Wales, Australia.
BJU international
|January 28, 2026
概括
前列腺组织切除的ProFocal激光疗法 (PFLT-PC) 试验显示,冷却激光焦点疗法 (cLFT) 在3个月内实现了前列腺癌治疗成功率的84%. 这种新的前列腺癌治疗方法显示出较低的发病率和短期的瘤结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 医疗器械 医疗器械
背景情况:
- 前列腺癌 (PCa) 治疗选择正在不断发展.
- 焦点治疗为PCa管理提供了有针对性的方法.
- 像冷却激光焦点疗法 (cLFT) 这样的新设备需要临床评估.
研究的目的:
- 评估前列腺组织切除 (PFLT-PC) 的ProFocal激光治疗试验的短期瘤结果.
- 评估ProFocal® cLFT设备在治疗局部性前列腺癌中的安全性和有效性.
- 为了确定与cLFT相关的功能结果和不良事件.
主要方法:
- 一项II期临床试验,涉及100名患有局部PCa的男性.
- 治疗涉及冷却激光焦点治疗 (cLFT) 在全身麻醉下.
- 通过MRI和活检评估瘤学适宜性;通过验证的问卷评估功能性结果;通过克拉维恩-丁多分类进行安全性.
主要成果:
- 84%的患者在治疗后3个月内没有达到国际泌尿病学学会 (ISUP) 评级组≥2PCa.
- 观察到的轻微功能影响:12%的人报告勃起功能障碍,男性性健康库存 (SHIM) 和扩大前列腺癌指数复合 (EPIC) -性评分的平均下降.
- 观察到EPIC-尿域得分下降4.5%,其他功能指标没有下降.
结论:
- PFLT-PC试验表明,使用ProFocal设备的CLFT在3个月内获得了84%的治疗成功.
- cLFT在局部性前列腺癌中表现出有利的安全性,患病率低.
- 由于没有对照组和短暂的随访期,需要进一步的研究.
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