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In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
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细胞外矩阵起源指导生物工程人类皮肤的形态发生和基因调节

Francesco Galardo1,2,3, Giorgia Imparato1, Costantino Casale1,3

  • 1Istituto Italiano Di Tecnologia-IIT, Center for Advanced Biomaterials For Healthcare, Napoli, Italy.

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生物制造功能性人体皮肤需要一种与原生皮肤相似的微环境. 内生细胞外基因矩阵 (ECM) 支持适当的基因表达和组织架构,与外生的支架不同,对于再生医学至关重要.

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这是一个ECM,ECM是ECM.在RNA-Seq,转录学.相当于全厚皮肤相当的全厚皮肤基因表达分析 基因表达分析器官类型的培养.

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科学领域:

  • 组织工程是组织工程.
  • 再生医学是一种再生医学.
  • 生物材料科学 生物材料科学

背景情况:

  • 细胞微环境,特别是细胞外基质 (ECM),为组织发育,修复和恒常提供了关键的生化和机械线索.
  • 通过指导转录程序,ECM指导细胞命运和功能.
  • 了解ECM起源的影响对于功能性组织的成功生物制造至关重要.

研究的目的:

  • 调查内源性与外源性细胞外基质 (ECM) 对人类皮肤等价物生物制造的影响.
  • 用不同的ECM源来比较皮肤结构的转录形状和结构特征.
  • 评估各种支架的适用性,以在体外创造生理上相关的皮肤组织.

主要方法:

  • 使用纤维细胞组装的内源性ECM和外源性基于原蛋白的支架,生物制造人类皮肤等效物.
  • 全厚皮肤模型的比较分析.
  • RNA测序用于评估转录轨迹.
  • 组织结构的组织学评估,包括皮肤-表皮结 (DEJ).

主要成果:

  • 在皮肤等价物中,ECM起源显著影响转录特征和形态遗传过程.
  • 与内源性产生的ECM相对应的皮肤表现出生理学上相关的架构和组织良好的DEJ.
  • 基于外源矩阵的构造显示出异常的上皮细胞扩张,并且未能复制关键的结构特征.

结论:

  • 复制原生细胞外基质 (ECM) 对于在体外产生功能性人类皮肤等价物至关重要.
  • 支架材料的选择深深地影响了工程组织的发展和结构完整性.
  • 这些发现对再生医学和组织工程应用中的支架选择具有关键意义.