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针对前列腺癌和临床显著前列腺癌的年龄调整PSAD的诊断效率:构建和诺莫格拉姆验证
Ziyang Liu1, Jiahao Shan1, Qiang Zhang2
1The First Clinical Medical College, Ningxia Medical University, Yinchuan, China.
Journal of clinical laboratory analysis
|January 28, 2026
概括
经年龄调整的前列腺特异性抗原密度 (A-PSAD) 提高了前列腺癌查准确度,高于标准PSA密度. 这种生物标志物减少了假阳性和不必要的活检,提高了个性化前列腺癌检测.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 生物标志物发现发现
背景情况:
- 前列腺特异性抗原 (PSA) 查前列腺癌 (PCa) 具有较低的特异性,导致假阳性和不必要的活检.
- 经年龄调整的前列腺特异性抗原密度 (A-PSAD) 是为了提高PCa和临床显著的PCa (csPCa) 查精度而开发的.
研究的目的:
- 为了评估A-PSAD的诊断性能与前列腺特异性抗原密度 (PSAD) 相比,用于PCa和csPCa检测.
- 开发和验证包含A-PSAD和其他临床变量用于改进PCa风险分层的诺莫格拉姆预测模型.
主要方法:
- 分析了663名接受前列腺活检的患者队列.
- 对比了A-PSAD和PSAD的诊断性能指标 (AUC,灵敏度,特异性).
- 拉索回归被用来选择名图模型的变量 (Nomo1,Nomo2与PI-RADS).
主要成果:
- 在PCa和csPCa的查中,A-PSAD表现优于PSAD,由更高的AUC值表明.
- 诺米克模型 (Nomo1) 实现了强大的预测性能,AUC为0.796 (训练) 和0.812 (验证).
- 将PI-RADS纳入Nomo2略有改善了高风险患者的表现,与Nomo1没有显著差异.
结论:
- 对于PCa查,A-PSAD提供了比PSAD更好的灵敏度和特异性的平衡.
- 开发的诺莫格拉姆模型显示了个性化PCa查的前景,可能减少不必要的活检.
- A-PSAD是一种有价值的生物标志物,可提高前列腺癌检测的准确性和效率.
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