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用鼠标MRI测试父亲饮食对子女神经解剖学的影响

Emma G W McKnight^1,2,3, Gail Lee^1,2,3, Cheryl Chong^1,4

¹Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

Brain and behavior

|January 28, 2026

概括

父亲食用高脂肪,高糖饮食并没有改变小鼠后代的大脑结构. 这些发现表明,母亲的饮食对于饮食引起的后代大脑发育变化至关重要.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
营养科学营养科学

背景情况:

父母的饮食显著影响后代的神经发育.
以前的研究主要集中在母亲的高脂肪,高糖 (HF/HSS) 饮食或父母的组合饮食上.
父亲的环境因素也可能影响后代的大脑发育.

研究的目的:

为了研究单独的父亲消费HF/HSS饮食对后代大脑结构的影响.
为了确定父亲的饮食本身是否可以诱导后代大脑形态的变化.
区分母亲与父亲饮食在饮食诱导的神经发育影响中的作用.

主要方法:

在交配前,雄性小鼠被食HF/HSS饮食八周;对照雄性接受标准食 (CD).
在整个孕期,哺乳期和断奶后,母婴和后代只食用CD.
后代的大脑使用ex vivo磁共振成像 (MRI) 和产后42天的体积分析进行了分析.

主要成果:

与对照组相比,受HF/HSS养的小羊表现出体重增加.
断奶时的后代体重 (P21) 和终点 (P42) 并没有受到父亲饮食的显著影响.
根据单独的 sire HF / HSS 饮食,没有观察到后代大脑形态的显著变化.

结论:

这项研究表明,单靠父亲的HF/HSS饮食并不能诱导后代大脑的显著结构变化.
与父母的HF/HSS饮食相关的观察到的后代大脑变化可能需要母亲的饮食贡献.
孕产妇的饮食在调节HF/HSS消费对后代大脑发育的影响方面发挥着至关重要的作用.

关键词:

这就是为什么MRI是MRI.高脂肪/高单糖的糖类.神经发育的神经发育父亲的饮食方式

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