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Updated: Jan 29, 2026

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REST误解突变揭示了子宫纤维瘤中被破坏的Re1动机结合和联合抑制剂相互作用

Srineevas Sriram1, Chandresh Palanichamy1, P T Subash1

  • 1Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

Frontiers in bioinformatics
|January 28, 2026
PubMed
概括

在Re1-Silencing转录因子 (REST) 中的结构性干扰可能会导致子宫纤维瘤 (UF). 在REST中的Y283C突变削弱了其DNA结合和与共抑制剂的相互作用,可能导致纤维瘤生长.

关键词:
模拟MDMD的模拟REST (re1-silencing转录因子) 是一个非常重要的转录因子.蛋白质-DNA对接对接蛋白质与蛋白质的对接这是一个re1图案.这是子宫纤维瘤.

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