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在接受rTMS的自闭症儿童中揭示异质的凝视模式:从潜伏形状分析的见解

Hong Liu¹, Chang Xu², Yingchen Xiao^3,4

¹Department of Mood Disorders II, Tianjin Anding Hospital, Tianjin, China.

Frontiers in psychiatry

|January 28, 2026

概括

患有自闭症谱系障碍 (ASD) 的儿童的目光模式,经历重复的跨磁刺激 (rTMS),可以预测不耐受. 识别特定的凝视行为可能有助于个性化rTMS治疗,以获得更好的结果.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
生物医学工程生物医学工程

背景情况:

重复性跨体磁性刺激 (rTMS) 显示出对自闭症谱系障碍 (ASD) 的治疗有前途.
目前缺乏预测在ASD中rTMS耐受性的客观标志物.
在rTMS期间了解ASD的目光行为对于治疗优化至关重要.

研究的目的:

探索经历rTMS的ASD儿童对情感面孔的目光行为变化.
根据目光模式识别ASD儿童的子组.
为了确定这些凝视子组是否与rTMS不耐受有关.

主要方法:

采集了104名自闭症儿童的眼睛跟踪数据,使用了偏好的外观模式.
使用隐形形状分析 (LPA) 来识别不同的凝视固定子组.
分析了人口统计学 (性别,年龄) 和临床 (CARS分数) 数据,以对视线形状和rTMS耐受性进行关联.

主要成果:

确定了三种不同的凝视特征:中度非偏好固定,低多元固定和轻微变化的增强固定.
在各个凝视配置文件中发现了性别和CARS得分的显著差异.
在已识别的视线配置文件中观察到越来越多的不耐受率 (38.1%至100%),该配置文件显著预测rTMS不耐受.

结论:

自闭症儿童表现出异质的情感面部凝视模式.
凝视行为变化可以作为在ASD中rTMS不耐受性的潜在客观标志物.
建议进行个性化rTMS干预,特别是对于具有较高CARS分数和特定注视模式表明更高不耐受风险的个体.

关键词:

自闭症谱系障碍 (ASD)眼神模式眼神模式眼神模式隐性个人资料分析 (LPA)重复的跨的磁性重复性刺激方式 (rTMS)这是一个宽容的宽容度.

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