评估微生物疗法作为精神病学治疗的长期影响:系统性审查
Cassandra Sgarbossa1,2,3, Arthi Chinna Meyyappan1,2,3, Evan Forth1,2,3
1Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Frontiers in psychiatry
|January 28, 2026
概括
针对肠道微生物群的微生物疗法显示出长期改善精神病症状的潜力,但需要更多的研究. 这次审查发现持续的情绪益处的结果不一,突出了需要更大规模的,安慰剂控制的研究.
科学领域:
- 精神病学是一个精神病学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠-大脑轴是心理疾病治疗的快速增长的研究领域.
- 微生物疗法为精神疾病提供了新的方法.
- 这些治疗方法的长度疗效仍未得到充分研究.
研究的目的:
- 审查评估肠道相关干预措施对情绪和精神症状的长期影响的研究.
- 总结关于微生物治疗药物在精神病学中的有效性随时间推移的发现.
主要方法:
- 在 2025 年 5 月 28 日之前,对四个数据库 (Embase,PsycINFO,Medline,Web of Science) 进行系统搜索.
- 包含的研究是同行评审的,用英语,并使用Cochrane手册进行质量评估.
- 十项临床研究符合资格标准.
主要成果:
- 报告了关于持续改善抑郁和焦虑症状 (3-18个月) 的混合发现.
- 一些研究表明持续的好处,而另一些报告没有长期改善.
- 随访时间的不一致性使得直接比较变得困难.
结论:
- 需要更多具有更大的样本大小的安慰剂对照研究来评估纵向潜力.
- 有证据表明,针对肠道微生物组来治疗情绪障碍的潜在长期益处.
- 进一步的研究至关重要,以建立微生物疗法作为可行的精神病治疗.
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