基于宏观尺度的噪音引起的听力损失中大脑网络拓和结构功能连接合的改变
Aijie Wang1, Xianghua Bao2, Chunye Wang1
1Department of Radiology, Yantaishan Hospital, Yantai, China.
Frontiers in neuroscience
|January 28, 2026
概括
噪音引起的听力损失 (NIHL) 改变了大脑网络拓,特别是增加了结构连接 (SC) 属性. 然而,功能连接 (FC) 和SC-FC合保持不变,与临床标记相关.
科学领域:
- 神经科学是一个神经科学.
- 图形理论 图形理论
- 医疗成像医学成像
背景情况:
- 噪音引起的听力损失 (NIHL) 是一个越来越令人担忧的潜在神经学影响.
- 在NIHL中,了解大脑的结构和功能网络变化至关重要.
研究的目的:
- 在NIHL中使用图形理论研究结构连接 (SC) 和功能连接 (FC) 的变化.
- 为了检查NIHL患者的整个大脑中SC-FC的拓合.
主要方法:
- 在57名NIHL患者和55名健康对照 (HCs) 中利用休息状态fMRI和扩散张力成像.
- 应用图形理论网络分析到SC和FC数据.
- 进行了全脑SC-FC合分析,并将研究结果与临床数据相关联.
主要成果:
- 全球功能连接 (FC) 指数在NIHL和HC之间没有显著差异.
- 与HC相比,NIHL患者在结构连接性 (SC) 中表现出更高的正常化聚类系数 (γ) 和小世界性 (σ).
- 两组之间没有观察到全脑SC-FC合强度的显著差异.
- 在NIHL中SC图形属性和合值与焦虑,凝血,炎症和生化标志物相关.
结论:
- NIHL与异常的大脑网络拓学有关,特别是在SC中,尽管FC和SC-FC合没有改变.
- 这些发现为理解NIHL中神经功能重塑提供了基础,并指导了未来的研究.
相关概念视频
Hearing
57.1K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
57.1K
Functions of Connective Tissues
16.4K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
16.4K
Protein Networks
4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Structural Protein Function
29.9K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
29.9K
Network Function of a Circuit
687
Frequency response analysis in electrical circuits provides vital insights into a circuit's behavior as the frequency of the input signal changes. The transfer function, a mathematical tool, is instrumental in understanding this behavior. It defines the relationship between phasor output and input and comes in four types: voltage gain, current gain, transfer impedance, and transfer admittance. The critical components of the transfer function are the poles and zeros.
687
Loss of Tumor Suppressor Gene Functions
6.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.1K


