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大脑结构,功能和认知变化之间的相关性在患有活期性结肠炎的患者中
Weijie Fan1, Wei Li1,2, Si Zhang1
1Department of Radiology, The Second Affiliated Hospital of Army Medical University, Chongqing, China.
Frontiers in neuroscience
|January 28, 2026
概括
性结肠炎 (UC) 患者显示大脑结构和功能变化与认知和情绪问题相关. 这些神经成像发现突出了UC中的肠-大脑轴,以及管理患者症状的潜在目标.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 医疗成像医学成像
背景情况:
- 主动性性结肠炎 (UC) 经常与情绪障碍和认知缺陷有关.
- 在UC患者中这些表现的潜在神经生物学机制尚不清楚.
- 这项研究旨在探索UC患者的神经结构和功能性大脑变化.
研究的目的:
- 研究活跃性结肠炎 (UC) 患者的神经结构和功能性大脑变化.
- 确定UC中情绪障碍和认知缺陷的潜在神经相关物.
- 探索UC中大脑变化,认知功能和临床评估之间的关系.
主要方法:
- 采用多模式MRI,包括结构MRI和静止状态功能MRI (rs-fMRI).
- 在45名活期UC患者和48名健康对照中评估认知功能和临床状态.
- 分析了区域神经活动,使用低频波动 (fALFF) 和灰色物质体积 (GMV) 的分数振幅.
主要成果:
- 患有UC的患者表现出注意力,工作记忆和执行功能受损,压力和焦虑得分增加.
- 在UC患者中观察到双边丘脑灰质体积 (GMV) 的减少.
- 改变的fALFF值在后带带状回环 (PCG),语言回环,额叶,叶和叶中被发现,与情绪和认知功能相关.
结论:
- 认知障碍和UC中的情绪异常与大脑的结构和功能变化有关,特别是在额叶,PCG和 thalamus.
- 结果表明UC中肠-大脑轴的激活是由于慢性炎症引起的.
- 特定的大脑区域可以作为预测和管理UC患者认知障碍的关键目标.
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