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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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大脑结构,功能和认知变化之间的相关性在患有活期性结肠炎的患者中.

Weijie Fan1, Wei Li1,2, Si Zhang1

  • 1Department of Radiology, The Second Affiliated Hospital of Army Medical University, Chongqing, China.

Frontiers in neuroscience
|January 28, 2026
PubMed
概括

性结肠炎 (UC) 患者显示大脑结构和功能变化与认知和情绪问题相关. 这些神经成像发现突出了UC中的肠-大脑轴,以及管理患者症状的潜在目标.

关键词:
认知障碍是一种认知障碍.低频波动的分数幅度的低频波动的分数幅度.肠-大脑轴 肠-大脑轴性结肠炎是一种基于voxel的形态测量方法

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科学领域:

  • 神经科学是一个神经科学.
  • 胃肠病学 胃肠病学
  • 医疗成像医学成像

背景情况:

  • 主动性性结肠炎 (UC) 经常与情绪障碍和认知缺陷有关.
  • 在UC患者中这些表现的潜在神经生物学机制尚不清楚.
  • 这项研究旨在探索UC患者的神经结构和功能性大脑变化.

研究的目的:

  • 研究活跃性结肠炎 (UC) 患者的神经结构和功能性大脑变化.
  • 确定UC中情绪障碍和认知缺陷的潜在神经相关物.
  • 探索UC中大脑变化,认知功能和临床评估之间的关系.

主要方法:

  • 采用多模式MRI,包括结构MRI和静止状态功能MRI (rs-fMRI).
  • 在45名活期UC患者和48名健康对照中评估认知功能和临床状态.
  • 分析了区域神经活动,使用低频波动 (fALFF) 和灰色物质体积 (GMV) 的分数振幅.

主要成果:

  • 患有UC的患者表现出注意力,工作记忆和执行功能受损,压力和焦虑得分增加.
  • 在UC患者中观察到双边丘脑灰质体积 (GMV) 的减少.
  • 改变的fALFF值在后带带状回环 (PCG),语言回环,额叶,叶和叶中被发现,与情绪和认知功能相关.

结论:

  • 认知障碍和UC中的情绪异常与大脑的结构和功能变化有关,特别是在额叶,PCG和 thalamus.
  • 结果表明UC中肠-大脑轴的激活是由于慢性炎症引起的.
  • 特定的大脑区域可以作为预测和管理UC患者认知障碍的关键目标.