修改后的EASIX评分在第7天预测了儿科急性白血病的存活率和非复发性死亡率,该患者接受了单独的干细胞移植
Kai Cui1, Senlin Zhang1, Yueke Du1
1Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China.
Frontiers in immunology
|January 28, 2026
概括
修改后的内皮激活和压力指数 (m-EASIX) 在第7天预测了接受平分异性供体移植的儿科白血病患者的结果. 高D7-m-EASIX得分表明死亡率和移植对宿主疾病的风险更高.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 移植医学 移植医学
背景情况:
- 内皮激活和压力指数 (EASIX) 是成人造血干细胞移植 (HSCT) 中验证的预后工具.
- 它的预后价值在患有骨髓缩条件 (MAC) 的儿科半同卵性供体移植 (HID) 中仍然不确定.
研究的目的:
- 评估EASIX及其修改版在接受HID-MAC.AC治疗的儿科白血病患者的预后意义.
- 确定可靠的生物标志物来预测这个特定患者群体的结果.
主要方法:
- 对接受HID-MAC.患者的儿科白血病患者的回顾性审查.
- 在多个时间点计算和对EASIX,sEASIX和m-EASIX的log2转换.
- 用最大选择的日志等级统计数据分为高/低 D7-m-EASIX 组进行分层.
主要成果:
- 在训练队列中,D7-m-EASIX>4.1独立预测了较差的整体存活率 (OS),无复发存活率 (RFS) 和非复发死亡率 (NRM).
- 高D7-m-EASIX也与严重急性移植对宿主疾病 (aGVHD) 的风险增加有关.
- 验证队列证实D7-m-EASIX是OS,RFS,NRM和aGVHD的重要预测因素.
结论:
- 修改后的内皮激活和压力指数 (m-EASIX) 计算在第7天 (D7-m-EASIX) 是一个有价值的预后生物标志物.
- 在接受HID-MAC.治疗的儿科白血病患者中,D7-m-EASIX有效预测了生存率和并发症.
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