病例报告:同步发生的自身免疫性胃炎和高度发育不良症在胃高可塑性息肉中
Tianwa Wang1, Jinfeng Luo1, Yajing Han2
1Department of Pathology (Longhua Branch), Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, China.
Frontiers in medicine
|January 28, 2026
概括
带有高度发育不良 (HGD) 的自身免疫性胃炎 (AIG) 需要超越常规护理的专业管理. 在AIG病例中,识别AIG在具有生殖不良的息肉中,以及生殖不良在AIG病例中,对于患者的治疗结果至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 自体免疫学 自体免疫学
背景情况:
- 自身免疫性胃炎 (AIG) 往往是低诊断的,其特征是身体占主导地位的氧化腺损失.
- 甲状腺炎创造了一个炎症环境,在这种环境中,高可塑性息肉是常见的,上皮质发育不良,虽然不那么频繁,但显著影响了管理.
- 同时的AIG和发育不良症带来了诊断和治疗方面的挑战.
研究的目的:
- 报告一种自身免疫性胃炎的病例,同时在胃聚体中存在高度发育不良.
- 强调认识到AIG和胃聚合物的发育不良之间的相互作用的重要性.
- 突出对患者管理和监测策略的影响.
主要方法:
- 一个35岁妇女的病例报告.
- 胃聚合物的内镜粘膜切除 (EMR).
- 组织病理学审查包括三级评估.
- 针对自身免疫标记物的血清检测 (抗细胞抗体,内在因子抗体).
- 检测Helicobacter pylori感染的情况.
主要成果:
- 最初的病理学发现了一种带有低度发育不良 (LGD) 的高可塑性息肉.
- 三级审查诊断出自身免疫性胃炎 (AIG) 与体受限性缩和转质形成,升级聚聚焦到高度发育不良 (HGD).
- 血清检测证实持续升高的抗parietal细胞抗体和胃素; * H. pylori * 呈阴性.
- 随访显示了治愈的EMR部位,持续的AIG和良性多发性多.
结论:
- 同时的AIG和HGD需要从标准的多叶切除术后护理转向最终切除和身体集中监测.
- 建议在胃息肉中检测到发育不良时积极考虑AIG.
- 相反,在已知的AIG患者中,应考虑患有形,促使仔细进行内镜评估.
相关概念视频
01:17Gastritis-II: Pathophysiology
1.2K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.2K
01:27Gastritis-I: Introduction and Types
2.3K
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
2.3K
01:19Graded Potential
7.0K
Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
7.0K
01:16Gastric Motility
3.1K
Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
3.1K
01:16Gastric Emptying
3.6K
Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
3.6K
01:15Types of Aggregate Grading
1.4K
Aggregate grading is crucial in economically obtaining a concrete mix with adequate strength, reasonable workability, and minimal segregation. There are four types of aggregate gradation: well-graded, uniformly (or one-sized) graded, gap-graded, and open-graded.
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
1.4K