作为过敏性鼻炎辅助剂的益生菌疗法:系统性审查和元分析的概述
Zhuang Wang1, Yongfu Song2, Xue Liang1,3
1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun City, Jilin Province, China.
Frontiers in medicine
|January 28, 2026
概括
益生菌辅助疗法显著缓解过敏性鼻炎症状,改善生活质量. 这一基于证据的概述支持益生菌作为过敏性鼻炎的安全有效治疗选择.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- 微生物组科学 微生物组科学
背景情况:
- 过敏性鼻炎是一种影响生活质量的普遍疾病.
- 目前对过敏性鼻炎的治疗方法有局限性.
- 益生菌正在探索它们在过敏疾病中的治疗潜力.
研究的目的:
- 综合来自系统审查和对过敏性鼻炎益生菌辅助治疗的元分析的证据.
- 提供基于证据的概述,以支持临床决策.
- 评估对过敏性鼻炎的益生菌现有研究的有效性,安全性和质量.
主要方法:
- 在多个数据库 (PubMed,Embase等) 中进行全面的文献搜索. 在2025年7月之前.
- 包括对过敏性鼻炎的益生菌辅助疗法的系统性审查和元分析.
- 对偏差风险的评估 (ROBIS),方法质量 (AMSTAR-2),报告质量 (PRISMA 2020) 和证据确定性 (GRADE).
- 文献重叠分析以评估重复率.
主要成果:
- 包括15个系统审查和元分析,偏差风险低.
- 益生菌辅助疗法在过敏性鼻炎患者中显著降低了乙素细胞数量.
- 定性综合表明症状缓解,改善生活质量和有利的安全概况.
结论:
- 益生菌在治疗过敏性鼻炎方面具有显著的辅助作用.
- 益生菌疗法有效缓解症状,提高生活质量.
- 益生菌的免疫调节作用,包括恢复Th1/Th2平衡,支持其临床应用.
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