677C/T基因多态和饮食习惯:对微量元素水平,氨基酸和生物化学参数的影响
Tatjana Orct1, Jelena Kovačić1, Ines Peremin2
1Institute for Medical Research and Occupational Health, Zagreb, Croatia.
Frontiers in nutrition
|January 28, 2026
概括
MTHFR 677C/T基因变异影响叶酸,和水平,特别是在素食者中. 这种MTHFR多态性也影响特定的氨基酸度,突出其在营养代谢中的作用.
科学领域:
- 营养基因组学 营养基因组学
- 生物化学 生物化学
- 人类遗传学 人类遗传学
背景情况:
- 叶酸和维生素B12水平会影响同型半氨酸和氨基酸的关联.
- 饮食习惯,特别是肉类消费,可能会影响营养的可用性.
- 在这些相互作用中,甲基四基叶酸还原酶 (MTHFR) 677C/T多态的作用需要进一步研究.
研究的目的:
- 研究MTHFR 677C/T多态化对元素和氨基酸水平的影响.
- 检查这些影响与饮食习惯 (非素食者与素食者) 相比.
主要方法:
- 研究人口:162名克罗地亚受试者.
- 基因定型:通过PCR-RFLP进行MTHFR 677C/T多态.
- 分析:元素通过ICP-QQQ,氨基酸通过GC-MS,生物化学参数通过免疫测试和酶方法.
- 统计分析:ANOVA和多重回归.
主要成果:
- 具有CT+TT MTHFR基因型的个体的叶酸水平比CC基因型更低.
- MTHFR 677C/T多态性影响了血 (CT+TT较高) 和 (素食CT+TT较低).
- CT+TT基因型与增加的谷氨酸,プロ林和酸水平有关,仅在素食者中葡萄糖含量升高.
结论:
- MTHFR 677C/T 多态性影响叶酸,特定元素和氨基酸水平.
- 需要进一步的研究才能充分理解MTHFR基因,元素和氨基酸之间的相互作用.
- 这些发现表明饮食和MTHFR基因型相互作用需要进行更深入的研究.
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