在使用辅助生殖技术怀孕的单子妊娠中,妊娠前的体重指数和早产之间的非线性关联
Tingting Zhuang1, Jingli Sun2, Yu Zhang2
1Postgraduate Training Base of Jinzhou Medical University (General Hospital of Northern Theater Command), Shenyang, China.
Frontiers in nutrition
|January 28, 2026
概括
该研究发现,在使用辅助生殖技术 (ART) 的妇女中,低和高的妊娠前体重指数 (BMI) 都会增加早产风险 (PTB). 最低PTB风险的最佳BMI大约为21.6kg/m2.
科学领域:
- 生殖健康 生殖健康
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 公共卫生 公共卫生
背景情况:
- 怀孕前的体重指数 (BMI) 是影响怀孕结果的关键因素.
- 辅助生殖技术 (ART) 的使用越来越多,需要了解其特定风险.
- 过早分娩 (PTB) 仍然是母亲健康的一个重大问题,特别是在ART群体中.
研究的目的:
- 调查怀孕前BMI与通过ART怀孕的女性PTB风险之间的关联.
- 确定与该人群中最低PTB风险相关的最佳妊娠前BMI范围.
- 根据先前的怀孕史,探索这种关联的潜在变异.
主要方法:
- 使用国家生命统计系统出生数据集 (2019-2023) 的回顾性队列研究.
- 包括197,237名通过ART怀孕的妇女,只有一次活产,并符合特定的年龄和妊娠年龄标准.
- 使用局限立方线的逻辑回归分析来评估非线性关联,并进行子组和灵敏度分析.
主要成果:
- 在怀孕前的BMI和PTB风险之间观察到显著的非线性关系 (P < 0.001).
- 在较低和较高的BMI水平上都注意到PTB风险增加.
- 最低的PTB风险与BMI大约为21.6kg/m2 (95%CI:21.3-21.9) 相关.
结论:
- 在ART群体中,妊娠前BMI和PTB之间存在非线性关联.
- 体重不足和超重/肥胖的BMI都与增加PTB风险有关.
- 妊娠前最佳的BMI约为21.6kg/m2与PTB风险最低相关,尽管这可能会因之前的怀孕流产而改变.
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