探索饮食因素与自闭症谱系障碍之间的潜在关联:孟德尔的随机化分析和回顾性研究
Yan-Shuo Guo1, Yu Wang1, Meng-Na Zhu1
1Department of Paediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China.
Frontiers in nutrition
|January 28, 2026
概括
遗传联系表明,全麦面食和奶酪粉可能会增加自闭症谱系障碍 (ASD) 的风险,而香可能具有保护作用. 无质,无素的饮食可能有助于调节ASD的免疫反应.
科学领域:
- 遗传学 是一个遗传学.
- 神经发育障碍 神经发育障碍
- 营养科学 营养科学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,受遗传和环境因素的影响.
- 研究饮食,食物过敏和自闭症风险之间的相互作用对于理解病因和制定干预措施至关重要.
研究的目的:
- 探索饮食因素,子,食物过敏和自闭症谱系障碍 (ASD) 风险之间的潜在因果关系.
- 评估无质,无素 (GFCF) 饮食在管理ASD症状和调节免疫反应方面的临床疗效.
主要方法:
- 利用两样本的门德尔随机化 (MR) 与全基因组关联研究 (GWAS) 数据分析199种饮食因素,类素和食物过敏与ASD风险的关联.
- 在78名儿童 (2-7岁) 上进行了一项回顾性临床研究,以评估GFCF饮食对ASD症状的影响,使用CARS和ADOS-2评分.
- 进行敏感性和调解分析以验证MR发现并探索潜在机制.
主要成果:
- 根据MR分析,潜在的ASD风险增加与基因倾向增加全麦面食和奶酪的摄入量有关,香有保护作用.
- 调解分析表明,奶酪散发的摄入量可能会通过免疫标记物 (如HLA-DR+ T细胞CD45水平和抗埃普斯坦-巴尔病毒IgG) 来影响ASD风险.
- 从临床上看,GFCF饮食虽然没有显著改变ADOS-2和CARS评分,但却显示出降低牛奶和小麦特异性IgG水平的能力,这表明免疫反应的调节.
结论:
- 这项研究提供了遗传证据,将特定的饮食模式与ASD风险联系起来,强调了饮食因素在神经发育中的重要性.
- 临床发现表明,GFCF饮食可以有效调节ASD儿童的食物特异性免疫反应.
- 这些结果有助于更好地了解ASD的起源,并支持优化营养策略来管理ASD症状.
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