在患有乳病的患者中增加IgE介导过敏的风险:一个病例对照研究
Ahemalali Azhati1,2,3, Shenglong Xue1,3,4, Tian Shi1,2,3
1Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Frontiers in nutrition
|January 28, 2026
概括
与健康个体相比,乳病 (CeD) 患者的IgE介导过敏率明显高. 在CeD中,并发性过敏可能会使腹等消化系统症状恶化,这表明需要进行过敏原查.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
背景情况:
- 病 (CeD) 是一种与过敏相关的自身免疫性疾病,但成年CeD患者的过敏的患病率和特征尚不清楚.
- 了解这些关联对于管理患有过敏并发症的CeD患者至关重要.
研究的目的:
- 确定中国人口中成年CeD患者过敏的患病率和临床特征.
- 为了比较CeD患者和健康对照者之间的过敏原资料.
主要方法:
- 招募了92名CeD患者和184名匹配的健康对照组.
- 评估过敏原配置文件,并对CeD患者的临床数据进行了回顾性分析,以检测过敏并发症和内镜特征.
主要成果:
- 在CeD患者中,IgE介导过敏的患病率明显高 (58.7%),高于对照组 (24.5%).
- 主要的过敏原包括牛奶,牛肉,小麦粉和狗皮质. 有过敏的CeD患者的BMI较低,腹发病率较高.
- 在性别,tTg-IgA水平或Marsh分类之间没有发现过敏和非过敏CeD组之间的显著差异.
结论:
- 在CeD患者中,IgE介导过敏的患病率显著增加.
- 伴随性过敏可以加剧肠道吸收不良和消化问题,特别是腹,在CeD.
- 对于患有严重吸收不良或耐火性腹的CeD患者,建议对过敏原进行查.
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