药物治疗方案复杂性指数与艾滋病毒/艾滋病患者的副作用的关联:一个回顾性队列研究
Ji Sun1,2, Hui Qi1,3, Jingmeng Huang4
1The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Frontiers in pharmacology
|January 28, 2026
概括
药物治疗方案复杂性指数 (MRCI) 在中国艾滋病毒/艾滋病患者住院后显著增加. 较高的MRCI水平与药物不良反应 (ADR) 的风险增加有关,突出了患者安全的关键因素.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 公共卫生 公共卫生
背景情况:
- 抗逆转录病毒疗法 (ART) 的复杂性在治疗艾滋病毒/艾滋病患者方面带来了挑战.
- 药物治疗方案复杂性指数 (MRCI) 是一种量化治疗复杂性的工具.
- 在此人群中,没有先前的研究探讨了MRCI和不良药物反应 (ADR) 之间的联系.
研究的目的:
- 调查中国获得免疫缺陷综合征 (艾滋病) 患者的MRCI和ADR之间的相关性.
- 为了确定影响MRCI和ADRs的因素,在这个患者群体.
主要方法:
- 对1010名患者进行了回顾性研究.
- 用于测量药理治疗复杂性的MRCI.
- 使用世界卫生组织-乌普萨拉监测中心 (WHO-UMC) 系统评估的副作用.
- 进行后勤回归分析以确定风险因素.
主要成果:
- MRCI显著增加,从入院前的4.09增加到出院后的6.09 (P < 0.0001).
- 影响MRCI的独立因素包括并发症 (>6种疾病),结核病药物和高药物计数 (>19).
- MRCI (>20.75) 是对副作用的独立风险因素 (OR: 1.42,P = 0.036),预测的AUC为0.58.
结论:
- 中国艾滋病毒/艾滋病患者的MRCI显著增加住院后.
- 较高的MRCI与经历ADRs的可能性更高有关.
- 在艾滋病毒/艾滋病管理中,MRCI作为预测ADR风险的有价值指标.
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