Jove
Visualize
联系我们

相关概念视频

Bile01:19

Bile

4.1K
Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
Bile is released when dietary fats enter...
4.1K
Therapeutic Index01:13

Therapeutic Index

6.7K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.7K
Subviral Agents01:29

Subviral Agents

556
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
556
Therapeutic Communication01:30

Therapeutic Communication

7.9K
Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
7.9K
Amino acids03:42

Amino acids

105.2K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
105.2K
Polyprotic Acids03:38

Polyprotic Acids

31.9K
Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
31.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The role of the neutrophil receptor Mrgpra2 in the formation of itch in atopic dermatitis.

bioRxiv : the preprint server for biology·2026
Same author

Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B.

Science signaling·2026
Same author

An Itch Receptor Drives Melanoma.

bioRxiv : the preprint server for biology·2026
Same author

Clinical utility of an evolving cholestasis gene panel in 10,000 children and adults.

Frontiers in pediatrics·2026
Same author

Mast cell-specific receptor MrgprB2 selectively mediates oxaliplatin-induced neuropathic pain.

Journal of translational medicine·2026
Same author

Optimizing approach to liver biochemistry abnormalities in cystic fibrosis pediatrics: Balancing efficiency and risk-benefit.

Clinics and research in hepatology and gastroenterology·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jan 29, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
08:42

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

11.6K

胆酸作为治疗剂的胆酸.

Brandon Vu1,2, Ryo Kawamoto1, Priscila Villalba-Davila3

  • 1Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Frontiers in pharmacology
|January 28, 2026
PubMed
概括

胆汁酸 (BAs) 显示了除了消化之外的治疗潜力,治疗肝脏疾病,如原发性胆汁胆道炎 (PBC) 等. 研究探讨了它们在胆固醇,代谢和神经退行性疾病中的应用.

关键词:
在 FXR 和 FXR 之间.在TGR5中,TGR5是TGR5.UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA UDCA胆酸疗法是一种胆酸疗法.胆汁酸 胆汁酸 胆汁酸双胞胎体中的双胞胎体.胆固醇的形成.神经保护神经保护

更多相关视频

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor
09:21

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor

Published on: January 4, 2016

10.4K
Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
06:34

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices

Published on: November 29, 2024

600

相关实验视频

Last Updated: Jan 29, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
08:42

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

11.6K
Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor
09:21

Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor

Published on: January 4, 2016

10.4K
Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
06:34

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices

Published on: November 29, 2024

600

科学领域:

  • 生物化学 生物化学
  • 药理学 药理学是指药理学的学科.
  • 肝病学 肝病学是一种肝病学.

背景情况:

  • 胆汁酸 (BAs) 是两性分子,对脂质消化至关重要.
  • 新兴研究强调了它们在各种疾病中的治疗潜力.
  • 乌尔索多西胆酸 (UDCA) 是FDA批准的用于原发性胆道胆道炎 (PBC).

研究的目的:

  • 审查已建立和新兴的基于胆酸的治疗方法.
  • 探索BA治疗效果的机制.
  • 讨论胆汁酸的新型药物输送系统.

主要方法:

  • 已建立和新兴的胆酸疗法的文献综述.
  • 分析胆汁酸调节的信号通路 (FXR,VDR,TGR5).
  • 检查影响BA疗效和毒性的物理化学性质.

主要成果:

  • 胆汁酸调节信号通路,减少肝损伤,调节炎症.
  • 最近批准的药物包括用于大脑肌性桑托马托सिस (CTX) 的陈氧胆酸 (CDCA).
  • 目前正在进行的试验正在研究用于治疗原发性硬化性胆道炎 (PSC) 的诺罗基酸 (NCA).

结论:

  • 胆酸提供治疗应用超越胆固醇性肝脏疾病,包括代谢和神经退行性疾病.
  • 了解BA的物理化学特性是优化疗效和最大限度地减少毒性的关键.
  • 对BA单一疗法,组合疗法和新型输送系统的进一步研究是有必要的.